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Structure of PDB 8fju Chain A

Receptor sequence >8fjuA (length=456) Species: 9606 (Homo sapiens) [Search protein sequence] WTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCL NNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYS GSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFES MPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCD EVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGARSGLIFY RKGVKADPKEIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPM FREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARA ERVLELVSITANKNTCPDRAITPGGLRLGAPALTSRQFREDDFRRVVDFI DEGVNIGLEVKSKTAKLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPM PGFDEH

3D structure PDB 8fju Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. Chain A Resolution 2.51 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 2.1.2.1: glycine hydroxymethyltransferase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 PLG A S76 S142 G143 S144 H171 T225 S226 D251 A253 H254 H279 K280 R425 S34 S100 G101 S102 H129 T183 S184 D209 A211 H212 H237 K238 R377 BS02 Y79 A L166 G169 G170 H171 L172 I183 S226 L124 G127 G128 H129 L130 I141 S184 BS03 PLG A Y96 Y106 G325 Y54 Y64 G279 BS04 Y79 A E98 Y105 E56 Y63

Gene Ontology Molecular Function GO:0003682 chromatin binding GO:0004372 glycine hydroxymethyltransferase activity GO:0005515 protein binding GO:0008732 L-allo-threonine aldolase activity GO:0016597 amino acid binding GO:0016740 transferase activity GO:0030170 pyridoxal phosphate binding GO:0042802 identical protein binding

	Biological Process
GO:0002082	regulation of oxidative phosphorylation
GO:0006544	glycine metabolic process
GO:0006545	glycine biosynthetic process
GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0008284	positive regulation of cell population proliferation
GO:0019264	glycine biosynthetic process from serine
GO:0034340	response to type I interferon
GO:0035999	tetrahydrofolate interconversion
GO:0046653	tetrahydrofolate metabolic process
GO:0051262	protein tetramerization
GO:0051289	protein homotetramerization
GO:0070129	regulation of mitochondrial translation
GO:0070536	protein K63-linked deubiquitination
GO:1903715	regulation of aerobic respiration

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0015630	microtubule cytoskeleton
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular exosome
GO:0070552	BRISC complex

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