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Structure of PDB 1diz Chain B

Receptor sequence >1dizB (length=282) Species: 562 (Escherichia coli) [Search protein sequence] MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTA IPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGA ARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFP EYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPG DVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTP AQIRRYAERWKPWRSYALLHIWYTEGWQPDEA

3D structure PDB 1diz DNA bending and a flip-out mechanism for base excision by the helix-hairpin-helix DNA glycosylase, Escherichia coli AlkA. Chain B Resolution 2.5 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) W218 Y222 D238 Catalytic site (residue number reindexed from 1) W218 Y222 D238 Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 dna B G123 Q124 L125 S127 V128 G214 I215 G216 W218 T219 D238 Y239 G123 Q124 L125 S127 V128 G214 I215 G216 W218 T219 D238 Y239 BS02 dna B L125 M174 P175 L125 M174 P175

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0003905 alkylbase DNA N-glycosylase activity GO:0005515 protein binding GO:0008725 DNA-3-methyladenine glycosylase activity GO:0016787 hydrolase activity GO:0032131 alkylated DNA binding GO:0043916 DNA-7-methylguanine glycosylase activity GO:0052821 DNA-7-methyladenine glycosylase activity GO:0052822 DNA-3-methylguanine glycosylase activity

	Biological Process
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006307	DNA alkylation repair
GO:0006950	response to stress
GO:0006974	DNA damage response

	Cellular Component
GO:0005737	cytoplasm
GO:0032993	protein-DNA complex

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