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Structure of PDB 7ni0 Chain B

Receptor sequence >7ni0B (length=738) Species: 88776 (Influenza A virus (A/Brevig Mission/1/1918(H1N1))) [Search protein sequence] MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS EKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF RSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQIGKKKQRLNKRSYL IRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQ SGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMF LAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQI PAEMLASIDLKYFNDSTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTV LGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYR TCKLLGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGIN ESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQI QTRRSFEIKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDE DYQGRLCNPLNPFVSHKEIESVNNAVMMPAHGPAKNMEYDAVATTHSWIP KRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAM VSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQ

3D structure PDB 7ni0 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies. Chain B Resolution 3.32 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 rna B N671 R672 N676 N653 R654 N658 BS02 rna B H32 G33 T34 Y38 K237 E358 H32 G33 T34 Y38 K219 E340

Gene Ontology Molecular Function GO:0000166 nucleotide binding GO:0003723 RNA binding GO:0003968 RNA-dependent RNA polymerase activity GO:0034062 5'-3' RNA polymerase activity

	Biological Process
GO:0001172	RNA-templated transcription
GO:0006351	DNA-templated transcription
GO:0019083	viral transcription
GO:0039523	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694	viral RNA genome replication

	Cellular Component
GO:0030430	host cell cytoplasm
GO:0042025	host cell nucleus

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