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Structure of PDB 7rfi Chain F

Receptor sequence >7rfiF (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] GHETAAQRYSARLLQAGYMADYLISGGTGYVPEDGLTAQQLFASADGLTY NDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDTVTEADMAIAM ALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPTLKEANAIIARTDL KKNRDYPLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQ GNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGC GSICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKAL ALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAVKIAQGVS GSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRT MSAQIEGGVHGLHSYTFLPFTK

3D structure PDB 7rfi IMPDH1 retinal variants control filament architecture to tune allosteric regulation. Chain F Resolution 2.6 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 1.1.1.205: IMP dehydrogenase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 GTP F K109 Q112 T225 D226 K229 K127 Q130 T148 D149 K152 BS02 GTP F E111 Q112 N198 L227 N230 K238 K242 E129 Q130 N142 L150 N153 K161 K165 BS03 IMP F S68 M70 R322 G328 S329 I330 C331 D364 G365 G387 S388 Y411 G413 M414 G415 Q441 S86 M88 R245 G251 S252 I253 C254 D287 G288 G310 S311 Y334 G336 M337 G338 Q347 BS04 NAD F T252 R253 D274 S276 Y282 N303 T333 T175 R176 D197 S199 Y205 N226 T256

Gene Ontology Molecular Function GO:0000166 nucleotide binding GO:0003824 catalytic activity GO:0003938 IMP dehydrogenase activity GO:0016491 oxidoreductase activity GO:0046872 metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm

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