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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	GNRHR
Synonym	LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R LHRH receptor GnRHR GNRHR1 luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor GnRH1 receptor [ Show all ]
Disease	Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease Prostate hyperplasia Unspecified Female infertility Esophageal cancer Endometriosis Controlled ovarian stimulation Cancer Advanced prostate cancer Acute lymphoblastic leukemia Hormone deficiency [ Show all ]
Length	328
Amino acid sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30968
Protein Data Bank	N/A
GPCR-HGmod model	P30968
3D structure model	This predicted structure model is from GPCR-EXP P30968.
BioLiP	N/A
Therapeutic Target Database	T12475
ChEMBL	CHEMBL1855
IUPHAR	256
DrugBank	BE0000203

Ligand

Name	CHEMBL185438
Molecular formula	C28H29ClN4O3S
IUPAC name	7-chloro-4-(2-cyclopentylethoxy)-2-oxo-N-(1,2,5-thiadiazol-3-yl)-3-(3,4,5-trimethylphenyl)-1H-quinoline-6-carboxamide
Molecular weight	537.075
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	6.5
Synonyms	L020823 7-Chloro-4-(2-cyclopentyl-ethoxy)-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide BDBM50155358
Inchi Key	ASVLYALZPZGNFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H29ClN4O3S/c1-15-10-19(11-16(2)17(15)3)25-26(36-9-8-18-6-4-5-7-18)21-12-20(22(29)13-23(21)31-28(25)35)27(34)32-24-14-30-37-33-24/h10-14,18H,4-9H2,1-3H3,(H,31,35)(H,32,33,34)
PubChem CID	10208964
ChEMBL	CHEMBL185438
IUPHAR	N/A
BindingDB	50155358
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	243.0 nM	PMID15482932	BindingDB,ChEMBL
IC50	1150.0 nM	PMID15482932	BindingDB,ChEMBL

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