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GLASS

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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	CHEMBL561577
Molecular formula	C23H26ClN3O3
IUPAC name	N-[4-(4-benzoylpiperazin-1-yl)-3-chlorophenyl]oxane-2-carboxamide
Molecular weight	427.929
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	BDBM50414456
Inchi Key	AGDFYYUNWFVFFS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H26ClN3O3/c24-19-16-18(25-22(28)21-8-4-5-15-30-21)9-10-20(19)26-11-13-27(14-12-26)23(29)17-6-2-1-3-7-17/h1-3,6-7,9-10,16,21H,4-5,8,11-15H2,(H,25,28)
PubChem CID	45269036
ChEMBL	CHEMBL561577
IUPHAR	N/A
BindingDB	50414456
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	316.23 nM	PMID19581086	BindingDB,ChEMBL

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