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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Cebranopadol
Molecular formula	C24H27FN2O
IUPAC name	6-fluoro-N,N-dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine
Molecular weight	378.491
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.3
Synonyms	HY-15536 SCHEMBL154336 W-6094 863513-91-1 BCP09612 Centrally-acting nociceptin agonist analgesic (oral liquid, pain/diabetic neuropathy), Grunenthal D10436 MolPort-039-063-422 Spiro(cyclohexane-1,1'(3'h)-pyrano(3,4-b)indol)-4-amine, 6'-fluoro-4',9'-dihydro-n,N-dimethyl-4-phenyl-, trans- (1r,4r)-6'-Fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine AK170452 BDBM50101112 GRT 6005 GRT6005 SCHEMBL10035739 US9120797, 24 6-fluoro-N,N-dimethyl-1'-phenylspiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine AKOS032953927 Cebranopadol [USAN:INN] D03TBJ KB-145997 SCHEMBL19336241 ZINC3950145 BDBM177926 CHEMBL2364605 DB12830 GRT 6005/06 NCGC00378895-01 trans-6'-Fluoro-n,N-dimethyl-4-phenyl-4',9''-dihydro-3'h-spiro(cyclohexane-1,1'-pyrano(3,4-b)indol)-4-amine AKOS025290738 CHEMBL3962932 GTPL8866 SCHEMBL14183935 US9120797, 25 7GDW9S3GN3 AS-35183 Cebranopadol(GRT-6005) D0R4YE KS-00000632 SCHEMBL566256 (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine A3296 BDBM50101095 CHEMBL3545616 EX-A1095 GRT-6005 SB16531 UNII-7GDW9S3GN3 6-Fluoro-N,N-dimethyl-1'-phenyl-spiro[4,9-dihydro-3H-pyrano[3,4-b]indole-1,4'-cyclohexane]-1'-amine AKOS025402576 Cebranopadol (USAN/INN) CS-1323 [ Show all ]
Inchi Key	CSMVOZKEWSOFER-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3
PubChem CID	11848225
ChEMBL	CHEMBL3962932
IUPHAR	8866
BindingDB	177926
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
553477	Delta-type opioid receptor	P41143	OPRD1	Homo sapiens (Human)	372
553472	Kappa-type opioid receptor	P34975	Oprk1	Rattus norvegicus (Rat)	380
553475	Kappa-type opioid receptor	P41145	OPRK1	Homo sapiens (Human)	380
443665	Mu-type opioid receptor	P35372	OPRM1	Homo sapiens (Human)	400
553473	Mu-type opioid receptor	P33535	Oprm1	Rattus norvegicus (Rat)	398
553474	Nociceptin receptor	P35370	Oprl1	Rattus norvegicus (Rat)	367
553476	Nociceptin receptor	P41146	OPRL1	Homo sapiens (Human)	370

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