Department of Computational Medicine and Bioinformatics Department of Biological Chemistry University of Michigan Medical School 100 Washtenaw Avenue Ann Arbor, MI 48109-2218 Phone: (734)647-1549 Fax: (734)615-6553 Email: zhanglabzhanggroup.org We are interested in: Protein Structure Prediction Protein Design and Protein Engineering Structure-based Protein Function Annotation SNP Mutation and Genetic Diseases Protein-Protein Interactions Ligand Docking and Structure-Based Drug Design

Determining structure and function of protein molecules is a cornerstone of modern biology and medicine. One of the main focuses of our lab is to develop computational methods to predict 3-dimensional structure of protein molecules from amino acid sequence, and to deduce the biological functions based on the sequence-to-structure-to-function paradigm. The second focus of our lab is to combine computational algorithms and biochemistry experiments to design new protein molecules with enhanced functionality beyond nature proteins. We are also working on modeling ligand-protein and protein-protein interactions, with particular interest in new drug screening targeting G protein-coupled receptors in the human genome ( >> read more ... ).

• PREDICTIONCENTER.ORG (2022/12/15): An updated version of I-TASSER, D-I-TASSER, was ranked as the No. 1 server in the 15th CASP experiment, in two categories of protein structure predictions including Multi-domain Targets, Single-domain Targets, and DMFold was ranked as the No. 1 predictor in protein complex structure prediction category (i.e., Multi-chain Targets). .
• CLARIVATE.COM (2022/11/18): Yang Zhang was selected as the 2022 Thomson Reuters/Clarivate Analytics Highly Cited Researcher. .
• INF.NEWS (2022/05/13): Zhang Yang's team reports a new algorithm for protein structure construction from cryo-EM images .

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