Department of Computer Science, School of Computing Department of Biochemistry, Yong Loo Lin School of Medicine Cancer Science Institute of Singapore Artificial Intelligence Institute National University of Singapore Computing 1, 13 Computing Drive Singapore 117417 Phone: +65-6601-1241 Email: zhanglabzhanggroup.org We are interested in: Protein Structure Prediction Protein Design and Protein Engineering Structure-based Protein Function Annotation SNP Mutation and Genetic Diseases Protein-Protein Interactions Ligand Docking and Structure-Based Drug Design

Understanding the structure and function of protein and RNA molecules lies at the heart of modern biology and medicine. A central focus of our lab is the development of computational methods to predict the three-dimensional structures of proteins and RNAs directly from their primary sequences, and to infer their biological functions through a sequence–structure–function framework. We are also actively exploring the integration of computational algorithms with biochemical experiments to design novel protein and RNA molecules with functionalities that surpass those found in nature. ( >> Read more ... ).

• CSI.NUS.EDU.SG (2025/3/19): Novel Sequence Searching Algorithm Significantly Boost the Power of AI-based Protein-Protein Complex Structure Prediction.
• SCIENCENET.CN (2024/12/2): Dr. Biao Zhang were awarded prestigious grant supports from both China Postdoctoral Science Foundation and Union Medical College Young Scholar Support Program .
• NSFC.GOV.CN (2024/10/10): Dr. Xi Zhang received support from National Natural Science Foundation of China (Young Scientists Fund) and Young Faculty Grant of Peking Union Medical College.

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