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Name | D(4) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD4 |
Synonym | D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor |
Disease | Erectile dysfunction Psychotic disorders Schizophrenia |
Length | 467 |
Amino acid sequence | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC |
UniProt | P21917 |
Protein Data Bank | 5wiv, 5wiu |
GPCR-HGmod model | P21917 |
3D structure model | This structure is from PDB ID 5wiv. |
BioLiP | BL0394824, BL0394826, BL0394825 |
Therapeutic Target Database | T24983 |
ChEMBL | CHEMBL219 |
IUPHAR | 217 |
DrugBank | BE0009376, BE0000389 |
Name | ISOCLOZAPINE |
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Molecular formula | C18H19ClN4 |
IUPAC name | 8-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine |
Molecular weight | 326.828 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 3.1 |
Synonyms | CHEMBL415300 SCHEMBL140207 1977-08-8 8-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine DTXSID40173464 [ Show all ] |
Inchi Key | APOMSSAGEAOUGO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-12-13(19)6-7-15(14)20-16-4-2-3-5-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
PubChem CID | 16104 |
ChEMBL | CHEMBL415300 |
IUPHAR | N/A |
BindingDB | 50010594 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 110.0 nM | PMID10377229 | BindingDB,ChEMBL |
Ki | 5.8 nM | PMID9577836, PMID9015795 | BindingDB |
Ki | 16.0 nM | PMID8064797 | BindingDB,ChEMBL |
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