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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	GNF-Pf-3343
Molecular formula	C21H27ClN4OS
IUPAC name	3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methylthieno[2,3-c]pyrazole-5-carboxamide
Molecular weight	418.984
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.3
Synonyms	BDBM51913 MCULE-8675634474 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide CHEMBL599943 NCGC00108997-01 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methylthieno[2,3-c]pyrazole-5-carboxamide HMS1826E01 C509-0116 MLS001199353 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-5-thieno[2,3-c]pyrazolecarboxamide cid_16007420 SMR000560359 AKOS001819039 HMS2875J05 MolPort-007-635-639 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-thieno[2,3-c]pyrazole-5-carboxamide ZINC5025926 [ Show all ]
Inchi Key	HGWOFUAZIPRWPO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H27ClN4OS/c1-4-11-26(12-5-2)13-10-23-20(27)18-14-17-19(24-25(3)21(17)28-18)15-6-8-16(22)9-7-15/h6-9,14H,4-5,10-13H2,1-3H3,(H,23,27)
PubChem CID	16007420
ChEMBL	CHEMBL599943
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92480.0 nM	PubChem BioAssay data set	ChEMBL

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