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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 3
Species	Rattus norvegicus (Rat)
Gene	Lpar3
Synonym	Edg7 endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7 LPA receptor 3 LPA-3 LPA3 receptor Lysophosphatidic acid receptor Edg-7 snGPCR32 [ Show all ]
Disease	N/A for non-human GPCRs
Length	354
Amino acid sequence	MNECHYDKRMDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWLLRQGLLDTSLTASLANLLVIAVERHMSIMRMRIHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVVVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCAPHDSNAERHPSRIPSTIHSRSDTGSQYLEDSISQGQVCNKSSS
UniProt	Q8K5E0
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4424
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL198406
Molecular formula	C24H40O5PS-
IUPAC name	hydroxy-[[2-[6-(4-octylphenyl)hexyl]-1,3-dioxolan-4-yl]methoxy]-oxido-sulfanylidene-lambda5-phosphane
Molecular weight	471.613
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	8.1
Synonyms	potassium O-(2-(6-(4-octylphenyl)hexyl)-1,3-dioxolan-4-yl)methyl O-hydrogenphosphorothioate BDBM50177334
Inchi Key	ABVKUFQLUUADAN-UHFFFAOYSA-M
Inchi ID	InChI=1S/C24H41O5PS/c1-2-3-4-5-6-9-12-21-15-17-22(18-16-21)13-10-7-8-11-14-24-27-19-23(29-24)20-28-30(25,26)31/h15-18,23-24H,2-14,19-20H2,1H3,(H2,25,26,31)/p-1
PubChem CID	58758382
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50177334
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	692.0 nM	PMID16290140	BindingDB

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