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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1773293
Molecular formula	C22H26N4O6S
IUPAC name	tert-butyl 4-[[3-(4-methylsulfonylphenyl)-[1,2]oxazolo[4,5-d]pyrimidin-7-yl]oxy]piperidine-1-carboxylate
Molecular weight	474.532
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	2.7
Synonyms	832717-22-3 GTPL5741 143144-EP2292620A2 tert-Butyl 4-((3-(4-methylsulfonylphenyl)-(1,2)oxazolo(5,4-E)pyrimidin-7-yl)oxy)piperidine-1-carboxylate compound 29a [PMID: 21444206] UNII-8L3B1I6V2T 143144-EP2287165A2 8L3B1I6V2T JYRWUSXRTGACLY-UHFFFAOYSA-N 4-(3-(4-Methanesulfonyl-phenyl)-isoxazolo(4,5-d)pyrimidin-7-yloxy)-piperidine-1-carboxylic acid tert-butyl ester tert-butyl 4-(3-(4-(methylsulfonyl)phenyl)isoxazolo[4,5-d]pyrimidin-7-yloxy)piperidine-1-carboxylate D06ACR 143144-EP2287166A2 BDBM50343445 SCHEMBL386450 4-[3-(4-Methanesulfonyl-phenyl)-isoxazolo[4,5-d]pyrimidin-7-yloxy]-piperidine-1-carboxylic acid tert-butyl ester compound 29a tert-butyl 4-[[3-(4-methylsulfonylphenyl)-[1,2]oxazolo[5,4-e]pyrimidin-7-yl]oxy]piperidine-1-carboxylate [ Show all ]
Inchi Key	JYRWUSXRTGACLY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26N4O6S/c1-22(2,3)31-21(27)26-11-9-15(10-12-26)30-20-19-18(23-13-24-20)17(25-32-19)14-5-7-16(8-6-14)33(4,28)29/h5-8,13,15H,9-12H2,1-4H3
PubChem CID	11397354
ChEMBL	CHEMBL1773293
IUPHAR	5741
BindingDB	50343445
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.7 nM	PMID21444206	BindingDB,IUPHAR,ChEMBL
Emax	100.0 %	PMID21444206	ChEMBL

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