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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000718725
Molecular formula	C16H18ClN5
IUPAC name	1-[(4-chlorophenyl)methyl]-N,N-diethylpyrazolo[3,4-d]pyrimidin-4-amine
Molecular weight	315.805
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.6
Synonyms	1-[(4-chlorophenyl)methyl]-N,N-diethyl-pyrazolo[3,4-d]pyrimidin-4-amine CHEMBL1327564 UPCMLD0ENAT5751748:001 AC1LHZLH HMS1428K07 SMR000290993 ZINC472452 1-[(4-chlorophenyl)methyl]-N,N-diethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine BDBM66555 IFLab1_005859 ST50056315 {1-[(4-chlorophenyl)methyl]pyrazolo[4,5-e]pyrimidin-4-yl}diethylamine 1-[(4-chlorophenyl)methyl]-N,N-diethylpyrazolo[3,4-d]pyrimidin-4-amine cid_895460 MolPort-000-437-706 VU0047513-1 AKOS000561760 HMS2718J14 SR-01000267968 [1-(4-Chloro-benzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-diethyl-amine 1-[(4-chlorophenyl)methyl]-N,N-diethyl-4-pyrazolo[3,4-d]pyrimidinamine MCULE-2475350808 STK106986 612523-77-0 F1405-0585 N-(1-(4-CHLOROBENZYL)-1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-YL)-N,N-DIETHYLAMINE Z57393563 1-(4-chlorobenzyl)-N,N-diethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine BAS 08139437 IDI1_011262 SR-01000267968-1 [1-(4-chlorobenzyl)pyrazolo[3,4-d]pyrimidin-4-yl]-diethyl-amine [ Show all ]
Inchi Key	ACOAELCHSHUBFK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H18ClN5/c1-3-21(4-2)15-14-9-20-22(16(14)19-11-18-15)10-12-5-7-13(17)8-6-12/h5-9,11H,3-4,10H2,1-2H3
PubChem CID	895460
ChEMBL	CHEMBL1327564
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	22387.2 nM	PubChem BioAssay data set	ChEMBL

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