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GPCR

Name	Vasopressin V2 receptor
Species	Homo sapiens (Human)
Gene	AVPR2
Synonym	AVPR V2 antidiuretic hormone receptor Renal-type arginine vasopressin receptor DIR3 ADHR V2 receptor V2R [ Show all ]
Disease	Euvolemic hyponatremia; Hypervolemic hyponatremia Enuresis; Polyuria; Diabetes insipidus Hypervolaemic hyponatraemia; Euvolaemic hyponatraemia Congestive heart failure Heart failure Nocturia Urinary incontinence Acute and chronic heart failure [ Show all ]
Length	371
Amino acid sequence	MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
UniProt	P30518
Protein Data Bank	N/A
GPCR-HGmod model	P30518
3D structure model	This predicted structure model is from GPCR-EXP P30518.
BioLiP	N/A
Therapeutic Target Database	T66237
ChEMBL	CHEMBL1790
IUPHAR	368
DrugBank	BE0000293

Ligand

Name	CHEMBL350090
Molecular formula	C24H19FN4O2S
IUPAC name	5-fluoro-2-methyl-N-[4-(13-thia-3,4,9-triazatricyclo[8.3.0.02,6]trideca-1(10),2(6),4,11-tetraene-9-carbonyl)phenyl]benzamide
Molecular weight	446.5
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.9
Synonyms	6-[4-(2-Methyl-5-fluorobenzoylamino)benzoyl]-2,4,5,6-tetrahydro-9-thia-1,2,6-triaza-9H-cyclopenta[e]azulene SCHEMBL5235980 BDBM50087555 L015176 N-[4-(4,5-Dihydro-2H-9-thia-1,2,6-triaza-cyclopenta[e]azulene-6-carbonyl)-phenyl]-5-fluoro-2-methyl-benzamide
Inchi Key	AYVDKTHMYIIUDD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H19FN4O2S/c1-14-2-5-17(25)12-19(14)23(30)27-18-6-3-15(4-7-18)24(31)29-10-8-16-13-26-28-21(16)22-20(29)9-11-32-22/h2-7,9,11-13H,8,10H2,1H3,(H,26,28)(H,27,30)
PubChem CID	19699097
ChEMBL	CHEMBL350090
IUPHAR	N/A
BindingDB	50087555
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	71.0 nM	PMID10782666	BindingDB,ChEMBL

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