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| Name | Vasopressin V2 receptor |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | AVPR2 |
| Synonym | AVPR V2 antidiuretic hormone receptor Renal-type arginine vasopressin receptor DIR3 ADHR [ Show all ] |
| Disease | Euvolemic hyponatremia; Hypervolemic hyponatremia Enuresis; Polyuria; Diabetes insipidus Hypervolaemic hyponatraemia; Euvolaemic hyponatraemia Congestive heart failure Heart failure [ Show all ] |
| Length | 371 |
| Amino acid sequence | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS |
| UniProt | P30518 |
| Protein Data Bank | N/A |
| GPCR-HGmod model | P30518 |
| 3D structure model | This predicted structure model is from GPCR-EXP P30518. |
| BioLiP | N/A |
| Therapeutic Target Database | T66237 |
| ChEMBL | CHEMBL1790 |
| IUPHAR | 368 |
| DrugBank | BE0000293 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 535910 |  SCHEMBL256565 | C25H29ClF3N5O5S | 604.042 | 10 / 2 | 4.5 | No |
| 3147 |  AC1N0YGA | C3H7NO4S | 153.152 | 5 / 2 | -4.7 | Yes |
| 3536 |  CHEMBL455418 | C34H27Cl2F2N5O2 | 646.52 | 6 / 2 | N/A | No |
| 4183 |  CHEMBL475129 | C26H32N4O4 | 464.566 | 4 / 1 | 2.6 | Yes |
| 4286 |  CHEMBL351654 | C26H23N3O2 | 409.489 | 2 / 2 | 4.7 | Yes |
| 4821 |  benzazepine derivative, 16 | C27H28ClN3O2 | 461.99 | 3 / 1 | 5.1 | No |
| 5209 |  CHEMBL430841 | C35H32ClN3O2 | 562.11 | 3 / 1 | 7.0 | No |
| 7745 |  CHEMBL432009 | C36H34ClN3O2 | 576.137 | 3 / 1 | 7.4 | No |
| 8575 |  CHEMBL432973 | C36H39FN4O3 | 594.731 | 5 / 2 | 5.6 | No |
| 9379 |  CHEMBL1817690 | C44H69N13O12S2 | 1036.23 | 16 / 11 | -3.5 | No |
| 9582 |  CHEMBL448195 | C32H25Cl2F2N5O2 | 620.482 | 6 / 2 | N/A | No |
| 9661 |  CHEMBL102311 | C30H30N2O3 | 466.581 | 3 / 1 | 6.2 | No |
| 10061 |  Phenypressin | C46H65N15O11S2 | 1068.24 | 15 / 13 | -4.5 | No |
| 10275 |  CHEMBL368818 | C38H42N4O4S | 650.838 | 6 / 1 | 5.8 | No |
| 10514 |  CHEMBL460319 | C24H29N3O4 | 423.513 | 4 / 2 | 3.3 | Yes |
| 11582 |  CHEMBL175930 | C29H26N2O3S | 482.598 | 4 / 1 | 5.8 | No |
| 13915 |  CHEMBL489386 | C18H19ClN4O3 | 374.825 | 6 / 0 | 2.6 | Yes |
| 536372 |  CHEMBL3954357 | C21H23ClF3N5O5S2 | 582.01 | 11 / 2 | 2.9 | No |
| 15037 |  CHEMBL165554 | C31H25N3O5S | 551.617 | 5 / 3 | 4.4 | No |
| 16217 |  CHEMBL515607 | C28H36N4O4 | 492.62 | 4 / 1 | 2.8 | Yes |
| 17818 |  CHEMBL350090 | C24H19FN4O2S | 446.5 | 5 / 2 | 3.9 | Yes |
| 18013 |  CHEMBL321656 | C40H42N4O3 | 626.801 | 4 / 2 | 6.7 | No |
| 19323 |  CHEMBL165200 | C43H44ClN5O2 | 698.308 | 4 / 1 | 7.3 | No |
| 19335 |  CHEMBL1790713 | C73H85N11O19S2 | 1484.66 | 21 / 15 | 3.7 | No |
| 20109 |  CHEMBL1085624 | C35H32ClNOS | 550.157 | 2 / 0 | 10.1 | No |
| 442489 |  CHEMBL3354586 | C46H73N11O12S | 1004.22 | 13 / 11 | -0.2 | No |
| 20787 |  CHEMBL349965 | C34H29N3O3 | 527.624 | 3 / 1 | 6.1 | No |
| 536502 |  CHEMBL3964694 | C22H21Cl2F3N6O4 | 561.343 | 8 / 4 | 2.6 | No |
| 21740 |  Terlipressin | C52H74N16O15S2 | 1227.38 | 19 / 16 | -5.8 | No |
| 465575 |  CHEMBL3186564 | C23H28ClN3O2 | 413.946 | 3 / 0 | 4.6 | Yes |
| 23729 |  CHEMBL2172288 | C66H63N9O12S | 1206.34 | 15 / 7 | 4.8 | No |
| 23744 |  CHEMBL2370641 | C50H73N9O9S2 | 1008.31 | 12 / 8 | 3.4 | No |
| 442625 |  CHEMBL3354600 | C46H67N11O12S2 | 1030.23 | 14 / 11 | -0.8 | No |
| 24886 |  CHEMBL93603 | C32H27ClFN3O3 | 556.034 | 5 / 1 | 5.4 | No |
| 24903 |  CHEMBL458635 | C26H25N3O4S | 475.563 | 7 / 0 | 4.3 | Yes |
| 553383 |  Lysipressin | C46H65N13O12S2 | 1056.22 | 16 / 13 | -3.9 | No |
| 25316 |  CHEMBL1819552 | C39H67N13O11S2 | 958.165 | 15 / 12 | -4.4 | No |
| 25352 |  CHEMBL1779406 | C34H39ClN4O6S | 667.218 | 8 / 0 | 4.7 | No |
| 25835 |  CHEMBL1837038 | C22H23ClN6O2 | 438.916 | 6 / 0 | 2.7 | Yes |
| 25987 |  CHEMBL590099 | C18H18ClN5O2 | 371.825 | 6 / 0 | 3.3 | Yes |
| 26776 |  CHEMBL136682 | C21H23ClN2O2 | 370.877 | 3 / 0 | 4.1 | Yes |
| 26986 |  CHEMBL372766 | C25H18F2N2O | 400.429 | 3 / 0 | 4.7 | Yes |
| 29075 |  CHEMBL516788 | C23H27N3O4 | 409.486 | 4 / 2 | 2.9 | Yes |
| 30001 |  CHEMBL2369845 | C46H65N13O11S2 | 1040.23 | 14 / 12 | -2.0 | No |
| 30004 |  CHEMBL411013 | C46H65N13O11S2 | 1040.23 | 14 / 12 | -2.0 | No |
| 30472 |  CHEMBL86936 | C32H37N5O2 | 523.681 | 5 / 0 | 5.1 | No |
| 31470 |  CHEMBL1084008 | C26H30N2O2 | 402.538 | 2 / 1 | 5.6 | No |
| 31820 |  CHEMBL1819541 | C42H65N13O12S2 | 1008.18 | 16 / 13 | -4.5 | No |
| 31950 |  CHEMBL314344 | C27H18ClF4N3O2 | 527.904 | 6 / 1 | 5.3 | No |
| 536821 |  SCHEMBL2443405 | C24H18Cl2F3N3O2 | 508.322 | 6 / 1 | 6.1 | No |
| 32101 |  CHEMBL166135 | C31H24ClN3O5S | 586.059 | 5 / 3 | 5.6 | No |
| 32786 |  CHEMBL472900 | C27H32N4O4 | 476.577 | 4 / 1 | 2.3 | Yes |
| 33054 |  memantine | C12H21N | 179.307 | 1 / 1 | 3.3 | Yes |
| 33814 |  CHEMBL334777 | C32H28N2O4S | 536.646 | 5 / 2 | 6.0 | No |
| 33816 |  CHEMBL128688 | C32H28N2O4S | 536.646 | 5 / 2 | 6.0 | No |
| 33843 |  CHEMBL475333 | C29H33N5O3 | 499.615 | 3 / 1 | 2.4 | Yes |
| 34090 |  CHEMBL432375 | C30H34N4O | 466.629 | 4 / 1 | 6.3 | No |
| 34299 |  CHEMBL455699 | C26H25F2N3O2 | 449.502 | 4 / 2 | 4.8 | Yes |
| 536882 |  SCHEMBL6928123 | C22H17Cl2F3N6O4 | 557.311 | 10 / 2 | 3.9 | No |
| 443032 |  CHEMBL3354598 | C49H71N11O12S | 1038.23 | 13 / 11 | 0.0 | No |
| 34677 |  CHEMBL87455 | C32H38N4O | 494.683 | 4 / 0 | 7.1 | No |
| 35268 |  CHEMBL96731 | C32H29N3O2S | 519.663 | 4 / 1 | 5.5 | No |
| 35270 |  CHEMBL329903 | C32H29N3O2S | 519.663 | 4 / 1 | 5.5 | No |
| 35273 |  CHEMBL327365 | C32H29N3O2S | 519.663 | 4 / 1 | 5.5 | No |
| 35507 |  CHEMBL131439 | C31H28N2O5S2 | 572.694 | 6 / 2 | 5.4 | No |
| 35884 |  CHEMBL1817698 | C44H69N13O12S2 | 1036.23 | 16 / 13 | -4.4 | No |
| 36534 |  CHEMBL475128 | C27H32F2N4O3 | 498.575 | 5 / 1 | 3.4 | Yes |
| 36856 |  CHEMBL318083 | C35H39FN4O3 | 582.72 | 5 / 2 | 5.5 | No |
| 38300 |  CHEMBL177248 | C37H44N4O3S | 624.844 | 6 / 1 | 6.6 | No |
| 38472 |  CHEMBL1779419 | C31H31ClN4O6S | 623.121 | 9 / 1 | 4.1 | No |
| 38655 |  CHEMBL166265 | C26H22FN3O2 | 427.479 | 3 / 2 | 4.8 | Yes |
| 39044 |  CHEMBL512349 | C31H42N4O4 | 534.701 | 4 / 1 | 3.8 | No |
| 443248 |  CHEMBL3354599 | C49H71N11O11S | 1022.23 | 12 / 10 | 0.3 | No |
| 39748 |  Relcovaptan | C28H27Cl2N3O7S | 620.498 | 8 / 2 | 3.8 | No |
| 39983 |  CHEMBL512257 | C20H18N6O2 | 374.404 | 7 / 0 | 1.2 | Yes |
| 537025 |  SCHEMBL255943 | C24H22ClF6N5O5 | 609.91 | 12 / 3 | 3.6 | No |
| 41470 |  CHEMBL606976 | C21H23F2N5O2 | 415.445 | 8 / 0 | 4.0 | Yes |
| 42319 |  CHEMBL455718 | C25H23F2N3O2 | 435.475 | 4 / 2 | 4.4 | Yes |
| 42860 |  CHEMBL1083731 | C26H33NO2 | 391.555 | 2 / 0 | 6.2 | No |
| 43797 |  benzazepine derivative, 20 | C25H23ClN2O3 | 434.92 | 3 / 2 | 4.4 | Yes |
| 44215 |  Cipargamin | C19H14Cl2FN3O | 390.239 | 3 / 3 | 3.9 | Yes |
| 44243 |  CHEMBL1817769 | C39H65N13O11S2 | 956.149 | 15 / 12 | -4.2 | No |
| 44758 |  CHEMBL2369831 | C45H63N13O12S2 | 1042.2 | 15 / 13 | -2.9 | No |
| 44760 |  CHEMBL405783 | C45H63N13O12S2 | 1042.2 | 15 / 13 | -2.9 | No |
| 45752 |  CHEMBL492029 | C20H24N4O3 | 368.437 | 6 / 0 | 2.7 | Yes |
| 46146 |  CHEMBL2370640 | C54H79N13O11S2 | 1150.43 | 14 / 11 | 1.1 | No |
| 553459 |  d(CH2)5[D-Ile2,Ile4]VP | C49H77N13O10S2 | 1072.36 | 13 / 12 | -0.3 | No |
| 46676 |  CHEMBL136644 | C20H21ClN2O | 340.851 | 2 / 1 | 4.9 | Yes |
| 443526 |  CHEMBL3354585 | C46H73N11O12S | 1004.22 | 13 / 11 | -0.2 | No |
| 47393 |  CHEMBL2369848 | C48H63N13O11S3 | 1094.29 | 15 / 12 | -1.5 | No |
| 47397 |  CHEMBL411485 | C48H63N13O11S3 | 1094.29 | 15 / 12 | -1.5 | No |
| 48325 |  CHEMBL601929 | C32H37ClN6O2S | 605.198 | 4 / 1 | 3.5 | No |
| 48998 |  CHEMBL590349 | C19H20ClN5O3 | 401.851 | 7 / 0 | 2.6 | Yes |
| 49573 |  CHEMBL334363 | C31H26F2N2O2S | 528.618 | 5 / 1 | 7.3 | No |
| 49890 |  CHEMBL480104 | C30H30Cl2F2N4O2 | 587.493 | 6 / 2 | N/A | No |
| 49972 |  CHEMBL1084326 | C30H33NO2 | 439.599 | 2 / 0 | 7.1 | No |
| 50150 |  CHEMBL1186825 | C30H29ClF2N4O2 | 551.035 | 6 / 1 | 5.0 | No |
| 50242 |  CHEMBL1819556 | C37H61N13O11S2 | 928.095 | 15 / 12 | -5.8 | No |
| 50811 |  CHEMBL330494 | C27H25ClFN3O2S | 510.024 | 5 / 1 | 5.0 | No |
| 517579 |  SCHEMBL2448621 | C23H19ClF3N5O | 473.884 | 6 / 1 | 4.9 | Yes |
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