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GLASS

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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	Cgs 15943
Molecular formula	C13H8ClN5O
IUPAC name	9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
Molecular weight	285.691
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.5
Synonyms	9-chloro-2-(2-furyl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine AC1Q3MS4 BRD-K49049886-001-03-8 CHEBI:131351 EU-0100324 L000176 MSJODEOZODDVGW-UHFFFAOYSA-N NCGC00015193-07 PDSP2_001076 SYN5006 ZINC3872013 9-chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-amine AOB33765 CHEMBL16687 HMS3261A09 LP00324 NCGC00015193-02 NCGC00025264-03 SCHEMBL3844736 9-chloro-2-(2-furanyl)-1,2,4-triazolo[1.5-c]quinazolin-5-amine [9-chloro-2-(furan-2-yl)-4H-[1,2,4]triazolo[1,5-c]quinazolin-5-yl]-amine 9-Chloro-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine(CGS 15943) BDBM50004566 CGS-15943, solid D0Q6WX I14-22041 MLS001423961 NCGC00015193-05 Nonnucleoside analog, 4 SR-01000075210-1 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine 9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine ACMC-20ddlj C-199 CHEBI:92849 GTPL384 Lopac-C-199 NC00042 NCGC00025264-01 SAM001246973 Tocris-1699 [1,2,4]Triazolo[1,5-c]quinazolin-5-amine, 9-chloro-2-(2-furanyl)- 9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine AS-16373 CGS 15943A CPD000449284 HMS3268O19 LS-184727 NCGC00015193-03 NCGC00025264-04 SMR000449284 9-chloro-2-(2-furanyl)-5,6-dihydro-1,2,4-triazolo (1,5-c)quinazolin-5-imine 9-chloro-2-(2-furyl)-5-imino-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazoline AC1L1E8T BN0142 CGS15943 DTXSID80146617 J-001205 MolPort-003-940-664 NCGC00015193-06 PDSP1_001092 104615-18-1 SR-01000075210-3 9-chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine AKOS015906465 CCG-100792 HMS2051C13 Lopac0_000324 NCGC00015193-01 NCGC00025264-02 SCHEMBL1906971 9-Chloro-2-(2-furanyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-amine Tox21_500324 [1,2,4]Triazolo[1,5-c]quinazolin-5-amine,9-chloro-2-(2-furanyl)- 9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine(CGS 15943) B6835 CGS-15943 CTK4A3171 HMS3393C13 MLS000758223 NCGC00015193-04 NCGC00261009-01 (1,2,4)Triazolo(1,5-c)quinazolin-5-amine, 9-chloro-2-(2-furanyl)- SR-01000075210 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine [ Show all ]
Inchi Key	MSJODEOZODDVGW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)
PubChem CID	2690
ChEMBL	CHEMBL16687
IUPHAR	384
BindingDB	50004566
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	1299.5 nM	PubChem BioAssay data set	ChEMBL
Potency	6309.6 nM	PubChem BioAssay data set	ChEMBL

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