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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	CHEMBL222955
Molecular formula	C12H8Cl2O4
IUPAC name	5-(2,5-dichlorophenyl)-5-methyl-4-oxofuran-2-carboxylic acid
Molecular weight	287.092
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.9
Synonyms	BDBM50208136 SCHEMBL3105646 5-(2,5-dichloro-phenyl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid
Inchi Key	NLWVUJBQWNYFGM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H8Cl2O4/c1-12(7-4-6(13)2-3-8(7)14)10(15)5-9(18-12)11(16)17/h2-5H,1H3,(H,16,17)
PubChem CID	11323649
ChEMBL	CHEMBL222955
IUPHAR	N/A
BindingDB	50208136
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	41000.0 nM	PMID17358052	BindingDB,ChEMBL

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