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Name | Cholecystokinin receptor type A |
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Species | Homo sapiens (Human) |
Gene | CCKAR |
Synonym | cholecystokinin-1 receptor CCK1-R CCK1 receptor CCK-AR CCK-A receptor [ Show all ] |
Disease | Pancreatic cancer; Obesity Eating disorder Pancreatic disease Gallstone prophylaxis; Obesity Gastrointestinal disease [ Show all ] |
Length | 428 |
Amino acid sequence | MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ |
UniProt | P32238 |
Protein Data Bank | 1d6g |
GPCR-HGmod model | P32238 |
3D structure model | This structure is from PDB ID 1d6g. |
BioLiP | BL0007611 |
Therapeutic Target Database | T28330 |
ChEMBL | CHEMBL1901 |
IUPHAR | 76 |
DrugBank | BE0000402 |
Name | CHEMBL1774043 |
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Molecular formula | C34H29FN4O4 |
IUPAC name | 3-[4-[4-(2-fluoro-4-methylphenyl)-5-(4-methoxyphenyl)pyrimidine-2-carbonyl]piperazin-1-yl]naphthalene-1-carboxylic acid |
Molecular weight | 576.628 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 1 |
XlogP | 6.1 |
Synonyms | BDBM50343721 3-(4-(4-(2-fluoro-4-methylphenyl)-5-(4-methoxyphenyl)pyrimidine-2-carbonyl)piperazin-1-yl)-1-naphthoic acid |
Inchi Key | SLFCKQWVMXDHDU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C34H29FN4O4/c1-21-7-12-27(30(35)17-21)31-29(22-8-10-25(43-2)11-9-22)20-36-32(37-31)33(40)39-15-13-38(14-16-39)24-18-23-5-3-4-6-26(23)28(19-24)34(41)42/h3-12,17-20H,13-16H2,1-2H3,(H,41,42) |
PubChem CID | 46869398 |
ChEMBL | CHEMBL1774043 |
IUPHAR | N/A |
BindingDB | 50343721 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 116.0 % | PMID21493064 | ChEMBL |
EC50 | 0.063 nM | PMID21493064 | BindingDB,ChEMBL |
IC50 | 0.22 nM | PMID21493064 | BindingDB,ChEMBL |
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