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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL92896
Molecular formula	C21H24ClFN2O
IUPAC name	2-[4-[4-chloro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethanol
Molecular weight	374.884
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	2-{4-[4-Chloro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethanol BDBM50029391 4-[[2,3-Dihydro-3-(4-fluorophenyl)-4-chloro-1H-inden]-1-yl]piperazine-1-ethanol
Inchi Key	ADWYWJGQPNBBNY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H24ClFN2O/c22-19-3-1-2-17-20(25-10-8-24(9-11-25)12-13-26)14-18(21(17)19)15-4-6-16(23)7-5-15/h1-7,18,20,26H,8-14H2
PubChem CID	15653098
ChEMBL	CHEMBL92896
IUPHAR	N/A
BindingDB	50029391
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	220.0 nM	PMID8410990, PMID7473566	BindingDB,ChEMBL

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