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Name | Vasopressin V1a receptor |
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Species | Homo sapiens (Human) |
Gene | AVPR1A |
Synonym | AVPR V1a AVPR Antidiuretic hormone receptor 1a AVPR1 V1A receptor [ Show all ] |
Disease | Euvolemic hyponatremia Hyponatraemia Dysmenorrhea Cardiotonic Infertility [ Show all ] |
Length | 418 |
Amino acid sequence | MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST |
UniProt | P37288 |
Protein Data Bank | N/A |
GPCR-HGmod model | P37288 |
3D structure model | This predicted structure model is from GPCR-EXP P37288. |
BioLiP | N/A |
Therapeutic Target Database | T79232 |
ChEMBL | CHEMBL1889 |
IUPHAR | 366 |
DrugBank | BE0000165 |
Name | CHEMBL327365 |
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Molecular formula | C32H29N3O2S |
IUPAC name | N-[4-(1,2,4,4a,5,11-hexahydro-[1,4]thiazino[3,4-c][1,4]benzodiazepine-6-carbonyl)phenyl]-2-phenylbenzamide |
Molecular weight | 519.663 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 5.5 |
Synonyms | Biphenyl-2-carboxylic acid [4-(3,4,11,11a-tetrahydro-1H,5H-2-thia-4a,10-diaza-dibenzo[a,d]cycloheptene-10-carbonyl)-phenyl]-amide L019922 BDBM50146292 |
Inchi Key | BXOKIJAEZHPQKJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C32H29N3O2S/c36-31(29-12-6-5-11-28(29)23-8-2-1-3-9-23)33-26-16-14-24(15-17-26)32(37)35-21-27-22-38-19-18-34(27)20-25-10-4-7-13-30(25)35/h1-17,27H,18-22H2,(H,33,36) |
PubChem CID | 9849525 |
ChEMBL | CHEMBL327365 |
IUPHAR | N/A |
BindingDB | 50146292 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 49.0 nM | PMID15125926 | BindingDB,ChEMBL |
Ki | 8000.0 nM | PMID15125926 | BindingDB,ChEMBL |
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