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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	CHEMBL21150
Molecular formula	C26H26ClN3OS
IUPAC name	(3E)-1-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-3-(thiophen-2-ylmethylidene)indol-2-one
Molecular weight	464.024
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.4
Synonyms	1-[3-[4-(3-Chlorophenyl)piperazino]propyl]-3-[(E)-(2-thienyl)methylene]indoline-2-one BDBM50099502 1-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-3-[1-thiophen-2-yl-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Inchi Key	AFHGICYMZHHOKC-LYBHJNIJSA-N
Inchi ID	InChI=1S/C26H26ClN3OS/c27-20-6-3-7-21(18-20)29-15-13-28(14-16-29)11-5-12-30-25-10-2-1-9-23(25)24(26(30)31)19-22-8-4-17-32-22/h1-4,6-10,17-19H,5,11-16H2/b24-19+
PubChem CID	44273919
ChEMBL	CHEMBL21150
IUPHAR	N/A
BindingDB	50099502
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	64.0 nM	PMID11354383	BindingDB,ChEMBL

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