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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS001079319
Molecular formula	C25H29N3O4S
IUPAC name	N-[2-(furan-2-yl)-2-piperidin-1-ylethyl]-4-[(4-methylphenyl)sulfamoyl]benzamide
Molecular weight	467.584
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.6
Synonyms	AKOS016867133 MolPort-009-510-371 CHEMBL1442774 N-[2-(furan-2-yl)-2-(piperidin-1-yl)ethyl]-4-[(4-methylphenyl)sulfamoyl]benzamide 1031515-94-2 MCULE-7313600783 SMR000709510 BDBM75550 N-[2-(2-furanyl)-2-(1-piperidinyl)ethyl]-4-[(4-methylphenyl)sulfamoyl]benzamide cid_24979260 N-[2-(furan-2-yl)-2-piperidin-1-yl-ethyl]-4-[(4-methylphenyl)sulfamoyl]benzamide Z31952279 N-[2-(2-furyl)-2-piperidino-ethyl]-4-(p-tolylsulfamoyl)benzamide HMS3035F10 N-[2-(furan-2-yl)-2-piperidin-1-ylethyl]-4-[(4-methylphenyl)sulfamoyl]benzamide [ Show all ]
Inchi Key	CHGMWIQKNZGDME-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H29N3O4S/c1-19-7-11-21(12-8-19)27-33(30,31)22-13-9-20(10-14-22)25(29)26-18-23(24-6-5-17-32-24)28-15-3-2-4-16-28/h5-14,17,23,27H,2-4,15-16,18H2,1H3,(H,26,29)
PubChem CID	24979260
ChEMBL	CHEMBL1442774
IUPHAR	N/A
BindingDB	75550
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10000.0 nM	PubChem BioAssay data set	ChEMBL

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