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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	AC1M7GFK
Molecular formula	C16H16Cl2N2OS
IUPAC name	3-(2,4-dichlorophenyl)-1-[(4-methoxyphenyl)methyl]-1-methylthiourea
Molecular weight	355.277
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.4
Synonyms	AKOS034377915 Z45890142 HMS2681N13 794577-19-8 MolPort-004-280-943 ZINC13656267 1-(2,4-dichlorophenyl)-3-[(4-methoxyphenyl)methyl]-3-methylthiourea MCULE-8235766546 SMR000376317 CHEMBL1419400 3-(2,4-dichlorophenyl)-1-[(4-methoxyphenyl)methyl]-1-methylthiourea MLS000807245 [ Show all ]
Inchi Key	AFMFEKWDDBTTOG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H16Cl2N2OS/c1-20(10-11-3-6-13(21-2)7-4-11)16(22)19-15-8-5-12(17)9-14(15)18/h3-9H,10H2,1-2H3,(H,19,22)
PubChem CID	2441554
ChEMBL	CHEMBL1419400
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	7079.5 nM	PubChem BioAssay data set	ChEMBL

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