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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	AC1LRTXJ
Molecular formula	C21H20BrN3O2
IUPAC name	4-bromo-N-cyclopentyl-N-[(4-oxo-3H-quinazolin-2-yl)methyl]benzamide
Molecular weight	426.314
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.8
Synonyms	ZINC17888955 4-Bromo-N-cyclopentyl-N-(4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-benzamide MLS000716411 AKOS000761334 CHEMBL1423439 4-bromo-N-cyclopentyl-N-[(4-oxo-1H-quinazolin-2-yl)methyl]benzamide SMR000277928 ASN 05812565 HMS2632G12 [ Show all ]
Inchi Key	AFRKXFPBSFJILQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H20BrN3O2/c22-15-11-9-14(10-12-15)21(27)25(16-5-1-2-6-16)13-19-23-18-8-4-3-7-17(18)20(26)24-19/h3-4,7-12,16H,1-2,5-6,13H2,(H,23,24,26)
PubChem CID	135417641
ChEMBL	CHEMBL1423439
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	31622.8 nM	PubChem BioAssay data set	ChEMBL

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