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Name | Glucose-dependent insulinotropic receptor |
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Species | Homo sapiens (Human) |
Gene | GPR119 |
Synonym | GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 [ Show all ] |
Disease | Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes |
Length | 335 |
Amino acid sequence | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG |
UniProt | Q8TDV5 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q8TDV5 |
3D structure model | This predicted structure model is from GPCR-EXP Q8TDV5. |
BioLiP | N/A |
Therapeutic Target Database | T93788 |
ChEMBL | CHEMBL5652 |
IUPHAR | 126 |
DrugBank | N/A |
Name | CHEMBL3325842 |
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Molecular formula | C20H26FN5O5S |
IUPAC name | propan-2-yl 4-[5-fluoro-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate |
Molecular weight | 467.516 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 1 |
XlogP | 2.6 |
Synonyms | BDBM50055992 |
Inchi Key | TUMNPBPSVJSXSL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H26FN5O5S/c1-12(2)30-20(27)26-9-7-14(8-10-26)31-19-17(21)18(22-11-23-19)25-15-5-6-16(24-13(15)3)32(4,28)29/h5-6,11-12,14H,7-10H2,1-4H3,(H,22,23,25) |
PubChem CID | 118711210 |
ChEMBL | CHEMBL3325842 |
IUPHAR | N/A |
BindingDB | 50055992 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 132.0 nM | PMID25088191 | BindingDB,ChEMBL |
Efficacy | 77.0 % | PMID25088191 | ChEMBL |
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