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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	AC1MD5HE
Molecular formula	C15H11ClF4N4O2
IUPAC name	2-chloro-6-fluoro-N-[[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]amino]carbamoyl]benzamide
Molecular weight	390.723
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	4.5
Synonyms	MLS000851352 SMR000457795 HMS2778O03 MolPort-002-897-172 ZINC1024308 MCULE-3640375054 2-chloro-6-fluoro-N-[[[6-methyl-4-(trifluoromethyl)pyridin-2-yl]amino]carbamoyl]benzamide N1-({2-[6-methyl-4-(trifluoromethyl)-2-pyridyl]hydrazino}carbonyl)-2-chloro-6-fluorobenzamide CHEMBL1509588 [ Show all ]
Inchi Key	AGFXUJKQMUVYCL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H11ClF4N4O2/c1-7-5-8(15(18,19)20)6-11(21-7)23-24-14(26)22-13(25)12-9(16)3-2-4-10(12)17/h2-6H,1H3,(H,21,23)(H2,22,24,25,26)
PubChem CID	2806016
ChEMBL	CHEMBL1509588
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	11220.2 nM	PubChem BioAssay data set	ChEMBL

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