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Name | 5-hydroxytryptamine receptor 2C |
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Species | Homo sapiens (Human) |
Gene | HTR2C |
Synonym | Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C [ Show all ] |
Disease | Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse [ Show all ] |
Length | 458 |
Amino acid sequence | MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV |
UniProt | P28335 |
Protein Data Bank | 6bqg, 6bqh |
GPCR-HGmod model | P28335 |
3D structure model | This structure is from PDB ID 6bqg. |
BioLiP | BL0404805, BL0404806 |
Therapeutic Target Database | T83813 |
ChEMBL | CHEMBL225 |
IUPHAR | 8 |
DrugBank | BE0004957, BE0004881, BE0000533 |
Name | CHEMBL575812 |
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Molecular formula | C13H17N5O3 |
IUPAC name | ethyl 4-(4-methylpiperazin-1-yl)-[1,2]oxazolo[5,4-d]pyrimidine-3-carboxylate |
Molecular weight | 291.311 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 0 |
XlogP | 1.1 |
Synonyms | CCG-183072 ethyl 4-(4-methylpiperazin-1-yl)isoxazolo[5,4-d]pyrimidine-3-carboxylate AKOS002009789 BDBM50298337 |
Inchi Key | AGGMAFMCVTYVQY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C13H17N5O3/c1-3-20-13(19)10-9-11(14-8-15-12(9)21-16-10)18-6-4-17(2)5-7-18/h8H,3-7H2,1-2H3 |
PubChem CID | 45482399 |
ChEMBL | CHEMBL575812 |
IUPHAR | N/A |
BindingDB | 50298337 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 2052.0 nM | PMID19464901 | BindingDB,ChEMBL |
Inhibition | 76.0 % | PMID19464901 | ChEMBL |
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