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GPCR

NameGalanin receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGalr1
SynonymGAL1 receptor
GAL1-R
GALNR
GALNR1
GALR-1
DiseaseN/A for non-human GPCRs
Length346
Amino acid sequenceMELAPVNLSEGNGSDPEPPAEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLFHRDSNQTFCWEHWPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPLTPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCRVCNESPHGDAKEKNRIDTPPSTNCTHV
UniProtQ62805
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5504
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3918185
Molecular formulaC11H11FO4S2
IUPAC name2-(3-fluorophenyl)-6,7-dihydro-5H-1,4-dithiepine 1,1,4,4-tetraoxide
Molecular weight290.323
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP0.8
Synonyms2-(3-Fluorophenyl)-6,7-dihydro-5H-1,4-dithiepin 1,1,4,4-tetraoxide
Inchi KeyGTQYRZXLKROVTC-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H11FO4S2/c12-10-4-1-3-9(7-10)11-8-17(13,14)5-2-6-18(11,15)16/h1,3-4,7-8H,2,5-6H2
PubChem CID9796013
ChEMBLCHEMBL3918185
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition23.9 %NoneChEMBL
Inhibition37.0 %NoneChEMBL
Inhibition38.9 %NoneChEMBL
Ratio8.27 -NoneChEMBL

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