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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●StarFunc ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

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●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

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GPCR

NameG-protein coupled receptor Mth
SpeciesDrosophila melanogaster (Fruit fly)
Genemth
SynonymProtein methuselah
DiseaseN/A for non-human GPCRs
Length514
Amino acid sequenceMKTLLVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILTGEYDFRILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDPFLNVTLDDGSVSRRHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRVTLRKREYCLQHLTFADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVKKLQNLHGKCFICYMVCLFMGYLFLLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVISLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQDWNPRVGHEGHCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHRQERKQKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFILFVLKRSTWRLLQESIRGEGEEVNNSEEEISLENTTTRNVLL
UniProtO97148
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3309000
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1221883
Molecular formulaC136H225N51O34S
IUPAC name(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-3-sulfanylpropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]propanoic acid
Molecular weight3150.68
Hydrogen bond acceptor45
Hydrogen bond donor59
XlogP-11.7
SynonymsN/A
Inchi KeyXVJYSCYRVTVKMN-SFNZVXLTSA-N
Inchi IDInChI=1S/C136H225N51O34S/c1-66(2)50-90(115(206)171-88(32-22-48-159-135(149)150)113(204)182-98(61-189)122(213)164-71(10)106(197)185-101(64-222)126(217)165-70(9)105(196)168-83(28-18-44-155-131(141)142)108(199)162-59-102(195)167-97(60-188)124(215)184-99(62-190)123(214)166-72(11)129(220)221)176-111(202)86(30-20-46-157-133(145)146)170-117(208)92(52-68(5)6)178-125(216)100(63-191)183-112(203)87(31-21-47-158-134(147)148)169-109(200)85(29-19-45-156-132(143)144)172-120(211)96(56-77-58-153-65-163-77)180-110(201)84(27-15-16-42-137)174-128(219)104(73(12)192)187-114(205)89(33-23-49-160-136(151)152)173-116(207)91(51-67(3)4)177-118(209)93(53-74-34-38-78(193)39-35-74)179-119(210)95(55-76-57-161-82-26-14-13-24-80(76)82)181-127(218)103(69(7)8)186-121(212)94(54-75-36-40-79(194)41-37-75)175-107(198)81(138)25-17-43-154-130(139)140/h13-14,24,26,34-41,57-58,65-73,81,83-101,103-104,161,188-194,222H,15-23,25,27-33,42-56,59-64,137-138H2,1-12H3,(H,153,163)(H,162,199)(H,164,213)(H,165,217)(H,166,214)(H,167,195)(H,168,196)(H,169,200)(H,170,208)(H,171,206)(H,172,211)(H,173,207)(H,174,219)(H,175,198)(H,176,202)(H,177,209)(H,178,216)(H,179,210)(H,180,201)(H,181,218)(H,182,204)(H,183,203)(H,184,215)(H,185,197)(H,186,212)(H,187,205)(H,220,221)(H4,139,140,154)(H4,141,142,155)(H4,143,144,156)(H4,145,146,157)(H4,147,148,158)(H4,149,150,159)(H4,151,152,160)/t70-,71-,72-,73+,81-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,103-,104-/m0/s1
PubChem CID49864472
ChEMBLCHEMBL1221883
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Kd>30.0 nMPMID17546039ChEMBL

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