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Name | Free fatty acid receptor 1 |
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Species | Homo sapiens (Human) |
Gene | FFAR1 |
Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
Length | 300 |
Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
UniProt | O14842 |
Protein Data Bank | 5tzy, 5tzr |
GPCR-HGmod model | O14842 |
3D structure model | This structure is from PDB ID 5tzy. |
BioLiP | BL0380462, BL0380463, BL0380464 |
Therapeutic Target Database | T25608 |
ChEMBL | CHEMBL4422 |
IUPHAR | 225 |
DrugBank | BE0000688 |
Name | CHEMBL3932664 |
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Molecular formula | C22H23FN4O3 |
IUPAC name | 5-[2-[(2R)-6-(5-cyclopropyloxy-2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-2-yl]ethyl]-2H-tetrazole |
Molecular weight | 410.449 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 4.5 |
Synonyms | BDBM50207059 |
Inchi Key | HDJUXRGWNBPXKN-MRXNPFEDSA-N |
Inchi ID | InChI=1S/C22H23FN4O3/c1-28-20-12-17(29-15-5-6-15)11-18(22(20)23)13-3-8-19-14(10-13)2-4-16(30-19)7-9-21-24-26-27-25-21/h3,8,10-12,15-16H,2,4-7,9H2,1H3,(H,24,25,26,27)/t16-/m1/s1 |
PubChem CID | 134138281 |
ChEMBL | CHEMBL3932664 |
IUPHAR | N/A |
BindingDB | 50207059 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <10000.0 nM | PMID28105282 | BindingDB,ChEMBL |
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