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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL11640
Molecular formula	C26H31N3O2
IUPAC name	1-[2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl]-4-pyridin-2-ylpiperazine
Molecular weight	417.553
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	5.0
Synonyms	BDBM50074864 1-[2-(4-Methoxy-3-phenethyloxy-phenyl)-ethyl]-4-pyridin-2-yl-piperazine; compound with oxalic acid CHEMBL1178026
Inchi Key	AACNPPGIALSYEJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H31N3O2/c1-30-24-11-10-23(21-25(24)31-20-13-22-7-3-2-4-8-22)12-15-28-16-18-29(19-17-28)26-9-5-6-14-27-26/h2-11,14,21H,12-13,15-20H2,1H3
PubChem CID	10621890
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50074864
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	295.0 nM	PMID10090790	BindingDB

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