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Name | Gastrin/cholecystokinin type B receptor |
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Species | Homo sapiens (Human) |
Gene | CCKBR |
Synonym | CCK-B receptor CCK-B receptor {ECO:0000303|PubMed:8415658} CCK-B/gastrin receptor CCK-BR gastrin/cholecystokinin type B receptor [ Show all ] |
Disease | Diagnostic imaging Duodenal ulcers Gastroesophageal reflux disease Gastrointestinal disease Intestine cancer [ Show all ] |
Length | 447 |
Amino acid sequence | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG |
UniProt | P32239 |
Protein Data Bank | N/A |
GPCR-HGmod model | P32239 |
3D structure model | This predicted structure model is from GPCR-EXP P32239. |
BioLiP | N/A |
Therapeutic Target Database | T05849 |
ChEMBL | CHEMBL298 |
IUPHAR | 77 |
DrugBank | BE0001158 |
Name | CHEMBL476531 |
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Molecular formula | C32H29ClN4O2 |
IUPAC name | [2-(4-chlorophenyl)-1-(3-ethoxyphenyl)imidazol-4-yl]-(4-naphthalen-2-ylpiperazin-1-yl)methanone |
Molecular weight | 537.06 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 6.9 |
Synonyms | BDBM50263062 SCHEMBL3127632 (2-(4-chlorophenyl)-1-(3-ethoxyphenyl)-1H-imidazol-4-yl)(4-(naphthalen-2-yl)piperazin-1-yl)methanone |
Inchi Key | DHORIKABYLAAOE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C32H29ClN4O2/c1-2-39-29-9-5-8-28(21-29)37-22-30(34-31(37)24-10-13-26(33)14-11-24)32(38)36-18-16-35(17-19-36)27-15-12-23-6-3-4-7-25(23)20-27/h3-15,20-22H,2,16-19H2,1H3 |
PubChem CID | 24785180 |
ChEMBL | CHEMBL476531 |
IUPHAR | N/A |
BindingDB | 50263062 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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Activity | 12.0 % | PMID18614364 | ChEMBL |
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