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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasoactive intestinal polypeptide receptor 1
Species	Rattus norvegicus (Rat)
Gene	Vipr1
Synonym	VIP-R1 VIP-R-1 VIP and PACAP receptor 1 RDC1 PVR2 Pituitary adenylate cyclase-activating polypeptide type II receptor PACAP-R2 PACAP-R-2 PACAP type II receptor HVR1 VPAC1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	459
Amino acid sequence	MRPPSPPHVRWLCVLAGALACALRPAGSQAASPQHECEYLQLIEIQRQQCLEEAQLENETTGCSKMWDNLTCWPTTPRGQAVVLDCPLIFQLFAPIHGYNISRSCTEEGWSQLEPGPYHIACGLNDRASSLDEQQQTKFYNTVKTGYTIGYSLSLASLLVAMAILSLFRKLHCTRNYIHMHLFMSFILRATAVFIKDMALFNSGEIDHCSEASVGCKAAVVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSVFITIWTVVRIYFEDFGCWDTIINSSLWWIIKAPILLSILVNFVLFICIIRILVQKLRPPDIGKNDSSPYSRLAKSTLLLIPLFGIHYVMFAFFPDNFKAQVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWSSKSQHPWGGSNGATCSTQVSMLTRVSPSARRSSSFQAEVSLV
UniProt	P30083
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1955712
IUPHAR	371
DrugBank	N/A

Ligand

Name	CHEMBL1956413
Molecular formula	C21H28OS
IUPAC name	[4-tert-butyl-2-(3-methylsulfanylphenyl)-6-propan-2-ylphenyl]methanol
Molecular weight	328.514
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.0
Synonyms	BDBM50366024
Inchi Key	FCZVDWWPWKSMOW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H28OS/c1-14(2)18-11-16(21(3,4)5)12-19(20(18)13-22)15-8-7-9-17(10-15)23-6/h7-12,14,22H,13H2,1-6H3
PubChem CID	57402678
ChEMBL	CHEMBL1956413
IUPHAR	N/A
BindingDB	50366024
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	170.0 nM	PMID22365758	BindingDB,ChEMBL

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