This page contains 3D structural models (Version 3, built on Aug 2014) of 1,026 putative G protein-coupled receptors (GPCRs) in the human genome generated by the GPCR-I-TASSER pipeline. The most recent (Version 4, built on June 2018) is now available as part of the GPCR-EXP database. In GPCR-I-TASSER, the GPCR sequences are first threaded through the GPCR template library to identify muliple structure templates by the LOMETS programs. When close homolgous templates are identified, full-length models will be constructed by the I-TASSER based fragment assembly simulations, assisted by a GPCR and membrane specific force field and spatial restraints collected from mutagenesis experiments in GPCR-RD. In case that homologous templates are not available, an ab initio folding procedure is used to assemble the 7-TM-helix bundle from scratch, followed by the GPCR-I-TASSER fragment reassembly simulations. For multiple domain GPCRs, structural models are built by GPCR-I-TASSER for each domain separately which are then reassembly by the I-TASSER approach. All the models are finally subjected to FG-MD for fragment-guided molecular dynamic simulation refinements. Note:
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Other GPCR-related resources
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HG ID | UniProt ID | Length | C-score | Estimated TM-score |
Estimated RMSD |
Top 5 models |
HG0100 | Q15612 | 314 | -0.2 | 0.69 ± 0.12 | 6.7 ± 4 | |
HG0101 | P20309 | 590 | -2.72 | 0.4 ± 0.14 | 9.99 ± 3.7 | |
HG0102 | Q15620 | 311 | 0.15 | 0.73 ± 0.11 | 6 ± 3.7 | |
HG0103 | Q8TDT2 | 470 | -3.49 | 0.33 ± 0.11 | 9.99 ± 3.2 | |
HG0104 | P21730 | 350 | -0.4 | 0.66 ± 0.13 | 7.4 ± 4.3 | |
HG0105 | P35348 | 466 | -3.08 | 0.37 ± 0.12 | 9.99 ± 3.6 | |
HG0106 | P47872 | 440 | -0.52 | 0.65 ± 0.13 | 8.2 ± 4.5 | |
HG0107 | Q8NGQ1 | 327 | -0.74 | 0.62 ± 0.14 | 8 ± 4.4 | |
HG0108 | Q8NGY4 | 312 | -0.36 | 0.67 ± 0.13 | 7.1 ± 4.1 | |
HG0109 | Q8NG77 | 320 | -0.32 | 0.67 ± 0.13 | 7 ± 4.1 | |
HG0110 | Q9H2C6 | 290 | 0.67 | 0.8 ± 0.09 | 4.7 ± 3.1 |
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