GPCR-I-TASSER is a computational method designed for 3D structure
prediction of G protein-coupled receptors.
The target sequence is first threaded through the PDB libary
to search for putative templates.
If homologous templates are identified, a template-based fragment
assembly procedure is used to construct full-length models. This
procedure is extended from
but with a GPCR-specific, knowledge-based force field to guide
the structure assembly simulations.
In case that no homologous templates are available, an
TM-helix folding procedure is used to
assembly the 7 transmembrane helix bundle from scratch, followed
by GPCR-I-TASSER structure reassembly simulation that is
assisted with the sparse mutagensis restraints from GPCR-RD
The final structue models are refined at atomic-level by
the fragment-guided molecular dynamic
Please report problems and questions at
Service System Discussion Board
and some members will study
and answer the questions.
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Note: This server is only for modeling GPCRs. For non-GPCR
sequences, please submit the sequences to the
If your sequence is a human GPCR, you can quickly retreive the model
results from the
All experimentally solved GPCRs can be found in the
The server currently is not working due to the internal problem.
You can try to use C-I-TASSER (https://zhanglab.dcmb.med.umich.edu/C-I-TASSER/) which also has a good performance on GPCR structure prediction.
We apologize for any inconvenience this may cause.
J Zhang, J Yang, R Jang, Y Zhang.
GPCR-I-TASSER: A hybrid approach to G protein-coupled receptor
structure modeling and the application to the human genome, Structure, 23: 1538-1549, 2015
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