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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	L-741,626
Molecular formula	C20H21ClN2O
IUPAC name	4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol
Molecular weight	340.851
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	3.7
Synonyms	L741,626 MolPort-003-943-618 NCGC00024932-01 PDSP2_001833 ( inverted question mark)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole ZINC6788 4-(4-Chloro-phenyl)-1-(1H-indol-3-ylmethyl)-piperidin-4-ol AC1L335F BRD-K05181463-001-04-0 DTXSID30230974 KUC112479N L-135 Lopac0_000742 NCGC00015591-03 NCGC00024932-04 SR-01000075973 1-((1H-indol-3-yl)methyl)-4-(4-chlorophenyl)piperidin-4-ol 4-(4-chlorophenyl)-1-(1h-indol-3-ylmethyl)piperidin-4-ol B6544 CHEBI:92090 HMS2230F17 L-741626 MFCD00953632 NCGC00015591-06 PDSP1_001848 Tocris-1003 3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole 81226-60-0 BPBio1_001094 CTK3I9542 HMS3370K05 L741626 NCGC00015591-01 NCGC00024932-02 SCHEMBL11253588 (+/-)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole 4-(4-CHLOROPHENYL)-1-(1H-INDOL-3-YL METHYL)PIPERIDIN-4-OL AC1Q3NO6 C20H21ClN2O EU-0100742 L 741,626 LP00742 NCGC00015591-04 NCGC00261427-01 SR-01000075973-1 4-Piperidinol, 4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)- BDBM50050467 HMS3262E06 L000887 MLS000860079 NCGC00015591-07 PDSP2_001399 ( inverted exclamation markA)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole Tox21_500742 3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole A19235 BRD-K05181463-001-01-6 D0M3PV KSC-315-034- Lopac-L-135 NCGC00015591-02 NCGC00024932-03 SMR000326937 4-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol AKOS024456330 CCG-204827 GTPL177 L 741626 L-741,626, >=98% (HPLC) LS-116920 NCGC00015591-05 PDSP1_001415 SR-01000075973-3 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole Biomol-NT_000036 CHEMBL445102 HMS3267M15 [ Show all ]
Inchi Key	LLBLNMUONVVVPG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
PubChem CID	133633
ChEMBL	CHEMBL445102
IUPHAR	177
BindingDB	50050467
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
190095	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
190097	5-hydroxytryptamine receptor 1A	P19327	Htr1a	Rattus norvegicus (Rat)	422
190087	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
190096	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
190088	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
556236	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
190081	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
190091	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
190093	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
190090	Alpha-2A adrenergic receptor	P22909	Adra2a	Rattus norvegicus (Rat)	450
190085	D(1A) dopamine receptor	P21728	DRD1	Homo sapiens (Human)	446
190083	D(1B) dopamine receptor	P21918	DRD5	Homo sapiens (Human)	477
190086	D(2) dopamine receptor	P14416	DRD2	Homo sapiens (Human)	443
556235	D(2) dopamine receptor	P61169	Drd2	Rattus norvegicus (Rat)	444
190084	D(3) dopamine receptor	P35462	DRD3	Homo sapiens (Human)	400
190082	D(4) dopamine receptor	P21917	DRD4	Homo sapiens (Human)	467
190092	Glucagon-like peptide 1 receptor	P43220	GLP1R	Homo sapiens (Human)	463
190089	Muscarinic acetylcholine receptor M1	P08482	Chrm1	Rattus norvegicus (Rat)	460
190094	Thyrotropin receptor	P16473	TSHR	Homo sapiens (Human)	764

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