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Name | P2Y purinoceptor 14 |
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Species | Homo sapiens (Human) |
Gene | P2RY14 |
Synonym | G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 [ Show all ] |
Disease | N/A |
Length | 338 |
Amino acid sequence | MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL |
UniProt | Q15391 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q15391 |
3D structure model | This predicted structure model is from GPCR-EXP Q15391. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4518 |
IUPHAR | 330 |
DrugBank | N/A |
Name | Udp-glucuronic acid |
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Molecular formula | C15H22N2O18P2 |
IUPAC name | (2S,3S,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
Molecular weight | 580.285 |
Hydrogen bond acceptor | 18 |
Hydrogen bond donor | 9 |
XlogP | -6.4 |
Synonyms | UGA Uridine 5'-diphospho-glucuronic acid Uridine diphospho-D-glucuronate Uridine-5'-Diphosphoglucuronic Acid a-D-Glucopyranuronic acid ester with uridine 5'-pyrophosphate [ Show all ] |
Inchi Key | HDYANYHVCAPMJV-LXQIFKJMSA-N |
Inchi ID | InChI=1S/C15H22N2O18P2/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26)/t4-,6-,7+,8+,9-,10-,11+,12-,14-/m1/s1 |
PubChem CID | 17473 |
ChEMBL | CHEMBL228057 |
IUPHAR | 1784 |
BindingDB | 50209665 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 63.0957 nM | PMID19339661 | IUPHAR |
EC50 | 370.0 nM | PMID19502066, PMID17407275 | BindingDB,ChEMBL |
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