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Name | P2Y purinoceptor 14 |
---|---|
Species | Homo sapiens (Human) |
Gene | P2RY14 |
Synonym | G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 [ Show all ] |
Disease | N/A |
Length | 338 |
Amino acid sequence | MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL |
UniProt | Q15391 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q15391 |
3D structure model | This predicted structure model is from GPCR-EXP Q15391. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4518 |
IUPHAR | 330 |
DrugBank | N/A |
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GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
---|---|---|---|---|---|---|
4854 | BDBM50303350 | C15H15ClN2O12P2-2 | 512.685 | 12 / 3 | -1.9 | No |
5497 | BPTU | C23H22F3N3O3 | 445.442 | 7 / 2 | 6.1 | No |
5640 | CHEMBL439378 | C16H28N2O16P2S | 598.406 | 17 / 9 | -5.5 | No |
10835 | CHEMBL1162563 | C11H21N3O11P2S | 465.307 | 13 / 6 | N/A | No |
15819 | CHEMBL566925 | C10H13F2IN2O11P2 | 564.066 | 13 / 6 | -3.8 | No |
24857 | CHEMBL596145 | C15H24N2O17P2 | 566.302 | 17 / 9 | -6.9 | No |
24858 | CHEMBL594065 | C15H24N2O17P2 | 566.302 | 17 / 9 | -6.9 | No |
27554 | 2-thio-UDP | C9H14N2O11P2S | 420.222 | 12 / 6 | -4.1 | No |
31386 | CHEMBL1085561 | C16H30IN3O11P2 | 629.278 | 12 / 6 | N/A | No |
34046 | CHEMBL1204010 | C10H18ClN3O12P2 | 469.661 | 12 / 7 | N/A | No |
37983 | CHEMBL2333771 | C26H31N3O2 | 417.553 | 3 / 2 | 6.6 | No |
47052 | CHEMBL1162554 | C10H19N3O12P2 | 435.219 | 13 / 6 | N/A | No |
459672 | 452105-23-6 | C23H27FN4O4 | 442.491 | 6 / 4 | 0.9 | Yes |
66858 | CHEMBL595940 | C15H24N2O16P2 | 550.303 | 16 / 8 | -6.1 | No |
69329 | CHEMBL594703 | C22H36N4O19P2 | 722.487 | 19 / 10 | -5.9 | No |
553627 | GTPL9471 | C41H47BF2N6O19P2S | 1070.66 | 23 / 10 | N/A | No |
73200 | CHEMBL1162557 | C10H19N3O11P2S | 451.28 | 13 / 6 | N/A | No |
74633 | CHEMBL1162556 | C13H25N3O11P2S | 493.361 | 13 / 6 | N/A | No |
81349 | BDBM50303345 | C13H16N2O12P2-2 | 454.221 | 12 / 3 | -3.8 | No |
81558 | CHEMBL1162552 | C13H25N3O12P2 | 477.3 | 13 / 6 | N/A | No |
553675 | CID 124221651 | C62H58F3N7O12S2 | 1214.3 | 20 / 7 | 6.5 | No |
553682 | PPTN | C29H24F3NO2 | 475.511 | 6 / 2 | 4.7 | Yes |
89252 | CHEMBL228111 | C15H24N2O16P2S | 582.363 | 17 / 9 | -6.0 | No |
460047 | Tozasertib | C23H28N8OS | 464.592 | 8 / 3 | 3.4 | Yes |
102461 | CHEMBL1085561 | C10H15IN2O11P2 | 528.085 | 11 / 6 | -4.5 | No |
102532 | CHEMBL612064 | C19H33N3O12P2 | 557.43 | 13 / 5 | N/A | No |
104005 | CHEMBL1084020 | C10H17N3O12P2 | 433.203 | 12 / 6 | -4.1 | No |
111093 | CHEMBL594064 | C15H23FN2O16P2 | 568.293 | 17 / 8 | -5.3 | No |
112446 | Udp-glucuronic acid | C15H22N2O18P2 | 580.285 | 18 / 9 | -6.4 | No |
112449 | BDBM50197975 | C15H20N2O18P2-2 | 578.269 | 18 / 7 | -6.6 | No |
112450 | CHEMBL1162071 | C15H22N2O18P2 | 580.285 | 18 / 9 | -6.4 | No |
553827 | alpha,beta-methylene-UDP | C12H20N2O8P2S | 414.306 | 9 / 4 | -1.8 | Yes |
115568 | CHEMBL226713 | C15H24N2O17P2 | 566.302 | 17 / 9 | -6.9 | No |
460272 | staurosporine | C28H26N4O3 | 466.541 | 4 / 2 | 3.2 | Yes |
122637 | Udp galactose | C15H24N2O17P2 | 566.302 | 17 / 9 | -6.3 | No |
122641 | UDP-glucose | C15H24N2O17P2 | 566.302 | 17 / 9 | -6.3 | No |
122647 | URIDINE-5'-DIPHOSPHATE-MANNOSE | C15H24N2O17P2 | 566.302 | 17 / 9 | -6.3 | No |
122648 | CHEMBL595216 | C15H24N2O17P2 | 566.302 | 17 / 9 | -6.3 | No |
128670 | CHEMBL594086 | C16H27N3O17P2 | 595.344 | 17 / 9 | -6.5 | No |
140510 | CHEMBL604700 | C15H24N2O16P2 | 550.303 | 16 / 8 | -5.9 | No |
149898 | CHEMBL1162559 | C15H21N3O12P2 | 497.29 | 13 / 6 | N/A | No |
153078 | CHEMBL488133 | C10H14F2N2O11P2 | 438.169 | 13 / 6 | -4.1 | No |
554029 | MRS2802 | C10H14F2N2O11P2 | 438.169 | 13 / 6 | -4.1 | No |
160480 | CHEMBL604267 | C16H26N2O16P2 | 564.33 | 16 / 9 | -6.0 | No |
164815 | BDBM50303344 | C12H18N2O11P2S-2 | 460.287 | 12 / 3 | -2.9 | No |
178360 | UDM | C18H29N3O16P2 | 605.383 | 16 / 9 | -6.8 | No |
554207 | UDP-N-acetylglucosamine | C17H27N3O17P2 | 607.355 | 17 / 9 | -6.6 | No |
186298 | UDP-N-acetyl-glucosamine | C17H25N3O17P2-2 | 605.339 | 17 / 7 | -6.5 | No |
186299 | CHEMBL1162072 | C17H27N3O17P2 | 607.355 | 17 / 9 | -6.6 | No |
187629 | CHEMBL611792 | C19H33N3O11P2S | 573.491 | 13 / 5 | N/A | No |
191279 | BDBM50303337 | C16H18N2O13P2-2 | 508.269 | 13 / 3 | -2.6 | No |
196758 | BDBM50303342 | C10H14N2O11P2S-2 | 432.233 | 12 / 3 | -3.7 | No |
461065 | Linifanib | C21H18FN5O | 375.407 | 4 / 4 | 3.9 | Yes |
214497 | CHEMBL612063 | C16H31N3O11P2 | 503.382 | 12 / 5 | N/A | No |
218951 | CHEMBL595076 | C19H30N4O18P2 | 664.407 | 18 / 10 | -7.3 | No |
222686 | CHEMBL1162562 | C16H23N3O13P2 | 527.316 | 14 / 6 | N/A | No |
222907 | CHEMBL593830 | C15H23FN2O16P2 | 568.293 | 17 / 8 | -5.6 | No |
226809 | CHEMBL1162558 | C15H27N3O12P2 | 503.338 | 13 / 6 | N/A | No |
231965 | CHEMBL605512 | C17H28N4O17P2 | 622.37 | 18 / 10 | -9.9 | No |
232024 | BDBM50303334 | C12H18N2O14P2-2 | 476.224 | 14 / 5 | -5.7 | No |
236550 | CHEMBL593125 | C15H23FN2O16P2 | 568.293 | 17 / 8 | -6.2 | No |
461270 | AST 487 | C26H30F3N7O2 | 529.568 | 10 / 3 | 3.8 | No |
240973 | 4-Thio-UDP | C9H14N2O11P2S | 420.222 | 12 / 6 | -4.1 | No |
245473 | BDBM50303347 | C13H20N2O11P2S-2 | 474.314 | 12 / 3 | -2.8 | No |
248594 | CHEMBL1162560 | C12H23N3O14P2 | 495.271 | 15 / 8 | N/A | No |
252318 | BDBM50303333 | C13H16N2O11P2S-2 | 470.282 | 12 / 3 | -3.2 | No |
256854 | CHEMBL507060 | C10H16N2O11P2 | 402.189 | 11 / 6 | -4.9 | No |
260832 | CHEMBL387520 | C15H22N2O17P2S | 596.346 | 18 / 9 | -5.8 | No |
267062 | CHEMBL2333772 | C25H29N3O2 | 403.526 | 3 / 2 | 6.1 | No |
267371 | BDBM50303343 | C11H16N2O11P2S-2 | 446.26 | 12 / 3 | -3.4 | No |
276597 | P1-uridyl-P2-methyl diphosphate | C10H14N2O12P2-2 | 416.172 | 12 / 3 | -4.3 | No |
285698 | CHEMBL1084020 | C16H32N4O12P2 | 534.396 | 13 / 6 | N/A | No |
554725 | MRS2905 | C11H18N2O10P2S | 432.277 | 11 / 6 | -4.4 | No |
293168 | CHEMBL1162555 | C12H20N4O12P2 | 474.256 | 14 / 6 | N/A | No |
303242 | CHEMBL612119 | C15H20N4O14P2 | 542.287 | 15 / 6 | N/A | No |
316932 | CHEMBL595467 | C14H22N2O16P2 | 536.276 | 16 / 8 | -6.2 | No |
316933 | CHEMBL593842 | C14H22N2O16P2 | 536.276 | 16 / 8 | -6.2 | No |
320744 | BDBM50303351 | C10H14N2O11P2-2 | 400.173 | 11 / 3 | -4.4 | No |
554923 | MRS 2690 | C15H22N2Na2O16P2S | 626.326 | 17 / 7 | N/A | No |
344144 | CHEMBL1743884 | C15H24N2O17P2 | 566.302 | 17 / 10 | -7.1 | No |
349200 | CHEMBL374384 | C15H24N2O16P2S | 582.363 | 17 / 9 | -6.0 | No |
349829 | BDBM50303349 | C15H15N3O14P2-2 | 523.24 | 14 / 3 | -2.7 | No |
350577 | BDBM50303338 | C10H14N2O10P2S-2 | 416.234 | 11 / 4 | -4.4 | No |
368335 | CHEMBL2333767 | C23H25N3OS | 391.533 | 3 / 2 | 5.9 | No |
370725 | BDBM50303332 | C12H15N3O12P2-2 | 455.209 | 13 / 3 | -4.7 | No |
462424 | Sunitinib | C22H27FN4O2 | 398.482 | 4 / 3 | 2.6 | Yes |
375501 | CHEMBL611791 | C16H31N3O10P2S | 519.443 | 12 / 6 | N/A | No |
377569 | BDBM50303346 | C13H20N2O12P2-2 | 458.253 | 12 / 3 | -3.4 | No |
381921 | CHEMBL593126 | C15H23FN2O16P2 | 568.293 | 17 / 8 | -6.2 | No |
382531 | CHEMBL2333773 | C22H20F3N3O3 | 431.415 | 7 / 2 | 5.6 | No |
388143 | Uridine 5'-diphosphate | C9H14N2O12P2 | 404.161 | 12 / 6 | -4.7 | No |
392887 | CHEMBL1162553 | C12H23N3O11P2S | 479.334 | 13 / 6 | N/A | No |
402627 | CHEMBL604676 | C15H24N2O17P2 | 566.302 | 17 / 9 | -6.9 | No |
421417 | CHEMBL612065 | C18H35N3O14P2 | 579.433 | 15 / 7 | N/A | No |
428561 | BDBM50303335 | C12H18N2O14P2-2 | 476.224 | 14 / 5 | -5.7 | No |
428882 | P1-uridyl-P2-phenyl diphosphate | C15H16N2O12P2-2 | 478.243 | 12 / 3 | -2.5 | No |
430401 | BDBM50303336 | C15H22N2O12P2-2 | 484.291 | 12 / 3 | -2.5 | No |
515957 | CHEMBL1199733 | C15H24N2O12P2 | 486.307 | 12 / 5 | -2.4 | No |
431448 | CHEMBL1162561 | C15H20ClN3O12P2 | 531.732 | 13 / 6 | N/A | No |
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