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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL563890
Molecular formula	C17H18ClN7O3
IUPAC name	2-[2-[[5-[(4-chlorophenyl)methyl]-1-(furan-3-yl)-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidine
Molecular weight	403.827
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	0.5
Synonyms	BDBM50294602 1-(2-(5-(4-chlorobenzyl)-1-(furan-3-yl)-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
Inchi Key	MECBNKHQRLUXQT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H18ClN7O3/c18-12-3-1-11(2-4-12)9-24-16(26)23-15(22-7-6-21-14(19)20)25(17(24)27)13-5-8-28-10-13/h1-5,8,10H,6-7,9H2,(H4,19,20,21)(H,22,23,26)
PubChem CID	45269816
ChEMBL	CHEMBL563890
IUPHAR	N/A
BindingDB	50294602
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1870.0 nM	PMID19375913	BindingDB,ChEMBL

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