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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL560451
Molecular formula	C19H27Cl2N7O2
IUPAC name	2-[2-[[5-[(3,4-dichlorophenyl)methyl]-1-hexyl-4,6-dioxo-1,3,5-triazin-2-yl]amino]ethyl]guanidine
Molecular weight	456.372
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.8
Synonyms	BDBM50294599 1-(2-(5-(3,4-dichlorobenzyl)-1-hexyl-4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-ylamino)ethyl)guanidine
Inchi Key	BDNLOAMMLSTYIO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H27Cl2N7O2/c1-2-3-4-5-10-27-17(25-9-8-24-16(22)23)26-18(29)28(19(27)30)12-13-6-7-14(20)15(21)11-13/h6-7,11H,2-5,8-10,12H2,1H3,(H4,22,23,24)(H,25,26,29)
PubChem CID	45267225
ChEMBL	CHEMBL560451
IUPHAR	N/A
BindingDB	50294599
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6510.0 nM	PMID19375913	BindingDB,ChEMBL

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