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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	mianserin
Molecular formula	C18H20N2
IUPAC name	5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene
Molecular weight	264.372
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.4
Synonyms	DSSTox_CID_3317 HSDB 7182 KBioGR_001820 mianserin a Mianserinum [INN-Latin] NCGC00015656-10 78684-63-6 PDSP1_001532 Biomol-NT_000135 SPBio_000986 BSPBio_000058 Tolvin (TN) CS-2078 DTXSID6023317 KBio1_000844 Lerivon Mianserina NCGC00015656-04 21535-47-7 (mono-hydrochloride) NCGC00024926-04 AKOS005216268 Prestwick1_000099 BPBio1_000331 Spectrum3_001836 CAS-24219-97-4 Tox21_110191_1 GTPL135 KBio2_007437 Mianserine [INN-French] 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine NCGC00015656-08 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene Norval (TN) API0000656 SBI-0050722.P003 BRD-A19661776-003-16-9 Spectrum_001810 Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- DSSTox_GSID_23317 HY-B0188 KBioSS_002303 Mianserin Monohydrochloride Mianseryna 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine NCGC00015656-12 AC-631 PDSP2_001516 Bolvidon (TN) SPBio_001997 BSPBio_003511 Tolvon (TN) D08216 EINECS 246-088-6 KBio2_002301 Lopac0_000744 Mianserina [INN-Spanish] (+-)-Athymil NCGC00015656-05 24219-97-4 NINDS_000844 AM20041174 Prestwick2_000099 BRD-A19661776-001-01-5 Spectrum4_001260 CCG-204829 UEQUQVLFIPOEMF-UHFFFAOYSA-N DB06148 DivK1c_000844 HMS2089A04 KBio3_003016 Mianserin (INN) Mianserinum 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine NCGC00015656-09 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(19),8,10,12,15,17-hexaene Oprea1_703627 BDBM50222218 SCHEMBL18020 BRN 0755346 Tolvan CHEMBL6437 DSSTox_RID_76974 IDI1_000844 L000736 Mianserin [INN:BAN] Mianseryna [Polish] 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine # NCGC00024926-03 AC1L1HLP Prestwick0_000099 BPBio1_000064 Spectrum2_001203 C18H20N2 Tox21_110191 D0R6RO FT-0697022 KBio2_004869 LS-61197 Mianserine NCGC00015656-06 5-methyl-2,5-diazatetracyclo[13.4.0.0;{2,7}.0;{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene Norval AN-15691 Prestwick3_000099 BRD-A19661776-003-05-2 Spectrum5_001772 CHEBI:51137 X5019 Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- [ Show all ]
Inchi Key	UEQUQVLFIPOEMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
PubChem CID	4184
ChEMBL	CHEMBL6437
IUPHAR	135
BindingDB	N/A
DrugBank	DB06148
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
IC50	114.82 nM	PMID11755364	ChEMBL
Ki	25.1189 - 50.1187 nM	PMID9298538	IUPHAR
Ki	56.0 nM	PMID15771415	PDSP,ChEMBL
Ki	63.1 nM	PMID14667218	ChEMBL
Ki	8010.0 nM	PMID12825922	ChEMBL

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