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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3622090
Molecular formula	C18H20ClFN4O
IUPAC name	[3-(5-chloro-3-methylpyridin-2-yl)-3-fluoropiperidin-1-yl]-[2-(methylamino)pyridin-4-yl]methanone
Molecular weight	362.833
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.8
Synonyms	BDBM50121328 SCHEMBL16760290
Inchi Key	KJJXBCYIKIOANE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20ClFN4O/c1-12-8-14(19)10-23-16(12)18(20)5-3-7-24(11-18)17(25)13-4-6-22-15(9-13)21-2/h4,6,8-10H,3,5,7,11H2,1-2H3,(H,21,22)
PubChem CID	91799673
ChEMBL	CHEMBL3622090
IUPHAR	N/A
BindingDB	50121328
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	290.0 nM	PMID26286844	BindingDB,ChEMBL

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