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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	UNM000000883401
Molecular formula	C24H30ClNO4S
IUPAC name	ethyl 4-[[(2-chlorophenyl)methyl-(4-methylphenyl)sulfonylamino]methyl]cyclohexane-1-carboxylate
Molecular weight	464.017
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	5.2
Synonyms	ethyl 4-[[(2-chlorophenyl)methyl-(4-methylphenyl)sulfonylamino]methyl]cyclohexane-1-carboxylate ZINC9490423 AKOS002126052 SCHEMBL1615796 CHEMBL3967689 EU-0029853 BDBM211171 SR-01000580059 ethyl 4-({(2-chlorobenzyl)[(4-methylphenyl)sulfonyl]amino}methyl)cyclohexanecarboxylate US9247759, 5-117 AC1NT3H8 MolPort-007-926-248 SR-01000580059-1 [ Show all ]
Inchi Key	MGJOLVWNJNFVJQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H30ClNO4S/c1-3-30-24(27)20-12-10-19(11-13-20)16-26(17-21-6-4-5-7-23(21)25)31(28,29)22-14-8-18(2)9-15-22/h4-9,14-15,19-20H,3,10-13,16-17H2,1-2H3
PubChem CID	5323270
ChEMBL	CHEMBL3967689
IUPHAR	N/A
BindingDB	211171
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2816.0 nM	N/A	BindingDB
IC50	2816.0 nM	None	ChEMBL

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