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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1278727
Molecular formula	C23H23NO6S
IUPAC name	4-[(3-methoxyphenyl)methyl-[(4-methoxyphenyl)methyl]sulfamoyl]benzoic acid
Molecular weight	441.498
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.5
Synonyms	BDBM211112 PBUSWPKWYSFCLW-UHFFFAOYSA-N 4-(N-(3-methoxybenzyl)-N-(4-methoxybenzyl)sulfamoyl)-benzoic acid CHEMBL3931168 US9247759, 5-34
Inchi Key	PBUSWPKWYSFCLW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23NO6S/c1-29-20-10-6-17(7-11-20)15-24(16-18-4-3-5-21(14-18)30-2)31(27,28)22-12-8-19(9-13-22)23(25)26/h3-14H,15-16H2,1-2H3,(H,25,26)
PubChem CID	25207618
ChEMBL	CHEMBL3931168
IUPHAR	N/A
BindingDB	211112
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2460.0 nM	None	ChEMBL
IC50	2460.0 nM	N/A	BindingDB

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