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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	N-(2,3-dimethylquinoxalin-6-yl)-1,4-dimethyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide
Molecular formula	C20H19N5O4S
IUPAC name	N-(2,3-dimethylquinoxalin-6-yl)-1,4-dimethyl-2,3-dioxoquinoxaline-6-sulfonamide
Molecular weight	425.463
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	1.4
Synonyms	BAS 14051627 N~6~-(2,3-dimethyl-6-quinoxalinyl)-1,4-dimethyl-2,3-dioxo-1,2,3,4-tetrahydro-6-quinoxalinesulfonamide CHEMBL3948049 ZINC9010485 AC1NS102 BRD-K61794953-001-01-4 SCHEMBL1278969 MCULE-9722487131 AKOS000645907 N-(2,3-dimethylquinoxalin-6-yl)-1,4-dimethyl-2,3-dioxoquinoxaline-6-sulfonamide STK272167 A3956/0168557 MolPort-002-028-082 [ Show all ]
Inchi Key	QNZGCWZGBMSSDR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19N5O4S/c1-11-12(2)22-16-9-13(5-7-15(16)21-11)23-30(28,29)14-6-8-17-18(10-14)25(4)20(27)19(26)24(17)3/h5-10,23H,1-4H3
PubChem CID	5301730
ChEMBL	CHEMBL3948049
IUPHAR	N/A
BindingDB	211233
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	6332.0 nM	None	ChEMBL
IC50	6332.0 nM	N/A	BindingDB

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