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GLASS

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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279324
Molecular formula	C21H18ClNO4S
IUPAC name	4-[benzyl-[(4-chlorophenyl)methyl]sulfamoyl]benzoic acid
Molecular weight	415.888
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.2
Synonyms	BDBM211143 US9247759, 5-137 CHEMBL3893065 US9247759, 5-77
Inchi Key	QWHLUCMKDMXEJW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H18ClNO4S/c22-19-10-6-17(7-11-19)15-23(14-16-4-2-1-3-5-16)28(26,27)20-12-8-18(9-13-20)21(24)25/h1-13H,14-15H2,(H,24,25)
PubChem CID	57422370
ChEMBL	CHEMBL3893065
IUPHAR	N/A
BindingDB	211143
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3977.0 nM	None	ChEMBL
IC50	3977.0 nM	N/A	BindingDB

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