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GLASS

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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1615476
Molecular formula	C23H27FN2O5S
IUPAC name	4-[[(4-acetamidophenyl)sulfonyl-[(4-fluorophenyl)methyl]amino]methyl]cyclohexane-1-carboxylic acid
Molecular weight	462.536
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	2.8
Synonyms	BDBM211177 US9247759, 5-124 CHEMBL3976205
Inchi Key	SWKSLDOHMMTRJW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H27FN2O5S/c1-16(27)25-21-10-12-22(13-11-21)32(30,31)26(15-18-4-8-20(24)9-5-18)14-17-2-6-19(7-3-17)23(28)29/h4-5,8-13,17,19H,2-3,6-7,14-15H2,1H3,(H,25,27)(H,28,29)
PubChem CID	57945011
ChEMBL	CHEMBL3976205
IUPHAR	N/A
BindingDB	211177
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	842.0 nM	N/A	BindingDB
IC50	842.0 nM	None	ChEMBL

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