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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	AC1LT76E
Molecular formula	C19H18N4O4S
IUPAC name	N-(2-cyano-3,5-dimethylphenyl)-1,3-dimethyl-2,4-dioxoquinazoline-6-sulfonamide
Molecular weight	398.437
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.3
Synonyms	N-(2-cyano-3,5-dimethylphenyl)-1,3-dimethyl-2,4-dioxoquinazoline-6-sulfonamide ZINC1422599 AKOS001735729 MCULE-3057786955 SCHEMBL1278670 A3475/0147357 N-(2-cyano-3,5-dimethylphenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide STK775902 CHEMBL3895501 [ Show all ]
Inchi Key	UAEXOTUMXRTFIH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H18N4O4S/c1-11-7-12(2)15(10-20)16(8-11)21-28(26,27)13-5-6-17-14(9-13)18(24)23(4)19(25)22(17)3/h5-9,21H,1-4H3
PubChem CID	1503534
ChEMBL	CHEMBL3895501
IUPHAR	N/A
BindingDB	211231
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1946.0 nM	N/A	BindingDB
IC50	1946.0 nM	None	ChEMBL

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