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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3983601
Molecular formula	C17H23ClN4O2S
IUPAC name	N-(4-chlorophenyl)-1-(1,3,5-trimethylpyrazol-4-yl)sulfonylpiperidin-4-amine
Molecular weight	382.907
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.0
Synonyms	US9475795, 51 BDBM250572 N-(4-Chlorophenyl)-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-amine SCHEMBL15549438 AIWRATIZFHITQS-UHFFFAOYSA-N
Inchi Key	AIWRATIZFHITQS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H23ClN4O2S/c1-12-17(13(2)21(3)20-12)25(23,24)22-10-8-16(9-11-22)19-15-6-4-14(18)5-7-15/h4-7,16,19H,8-11H2,1-3H3
PubChem CID	72550225
ChEMBL	CHEMBL3983601
IUPHAR	N/A
BindingDB	250572
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1500.0 nM	, None	BindingDB,ChEMBL

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