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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prokineticin receptor 1
Species	Homo sapiens (Human)
Gene	PROKR1
Synonym	VEGFR-1 PKR1 PK-R1 GPR73a GPR73 G-protein coupled receptor ZAQ G-protein coupled receptor 73 G protein-coupled receptor 73 ZAQ [ Show all ]
Disease	N/A
Length	393
Amino acid sequence	METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
UniProt	Q8TCW9
Protein Data Bank	N/A
GPCR-HGmod model	Q8TCW9
3D structure model	This predicted structure model is from GPCR-EXP Q8TCW9.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5649
IUPHAR	335
DrugBank	N/A

Ligand

Name	CHEMBL3894644
Molecular formula	C18H24Cl2N4O2S
IUPAC name	N-(3,4-dichlorophenyl)-N-methyl-1-(1,3,5-trimethylpyrazol-4-yl)sulfonylpiperidin-4-amine
Molecular weight	431.376
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.8
Synonyms	US9475795, 54 BDBM250575 SCHEMBL16657615
Inchi Key	BIWARYDJUHLCPS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H24Cl2N4O2S/c1-12-18(13(2)23(4)21-12)27(25,26)24-9-7-14(8-10-24)22(3)15-5-6-16(19)17(20)11-15/h5-6,11,14H,7-10H2,1-4H3
PubChem CID	118027522
ChEMBL	CHEMBL3894644
IUPHAR	N/A
BindingDB	250575
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5200.0 nM	, None	BindingDB,ChEMBL

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